CAS 76296-75-8|Polyphyllin G

Introduction：Basic information about CAS 76296-75-8|Polyphyllin G, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Polyphyllin G BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Polyphyllin G
CAS Number	76296-75-8	Molecular Weight	1049.199
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₅₁H₈₄O₂₂	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Polyphyllin VII
Synonym	More Synonyms

Polyphyllin G BiologicalActivity

Description	Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs)[1].Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy[2].
Related Catalog	Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/Immunology
References	[1]. Cai X, et al. Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2. Arch Biochem Biophys. 2018 Apr 15;644:93-99. [2]. Hsieh MJ, et al. Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. Phytomedicine. 2016 Dec 1;23(13):1545-1554.

Description

Polyphyllin G is isolated from the rhizomes of Paris yunnanensis, with antimicrobial and anticancer activity. Polyphyllin G prevents the growth of both Gram-positive and Gram-negative bacteria with minimum inhibitory concentrations (MICs)[1].Polyphyllin G induces apoptosis dependent on the activations of caspase-8, -3, and -9, induces autophagy[2].

Related Catalog

Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/Immunology

References

[1]. Cai X, et al. Polyphyllin G exhibits antimicrobial activity and exerts anticancer effects on human oral cancer OECM-1 cells by triggering G2/M cell cycle arrest by inactivating cdc25C-cdc2. Arch Biochem Biophys. 2018 Apr 15;644:93-99.

[2]. Hsieh MJ, et al. Polyphyllin G induces apoptosis and autophagy cell death in human oral cancer cells. Phytomedicine. 2016 Dec 1;23(13):1545-1554.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₅₁H₈₄O₂₂
Molecular Weight	1049.199
Exact Mass	1048.545410
PSA	335.06000
LogP	3.76
Index of Refraction	1.623
InChIKey	GJHYVTIBXQFLKG-ZAOCAYBASA-N
SMILES	COC1(CCC(C)COC2OC(CO)C(O)C(O)C2O)OC2CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(CO)C(O)C7O)C(OC7OC(C)C(O)C(O)C7O)C6O)CCC5(C)C4CCC3(C)C2C1C

Safety Information

Hazard Codes	Xi

Synonyms

(3β,22S,25R)-3-{[α-L-Arabinofuranosyl-(1->4)-[6-deoxy-α-L-mannopyranosyl-(1->3)]-β-L-glucopyranosyl]oxy}-22-methoxyfurost-5-en-26-yl β-D-glucopyranoside

β-D-Glucopyranoside, (3β,22α,25R)-3-[[O-α-L-arabinofuranosyl-(1->4)-O-[6-deoxy-α-L-mannopyranosyl-(1->3)]-β-L-glucopyranosyl]oxy]-22-methoxyfurost-5-en-26-yl

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