Introduction：Basic information about CAS 95041-90-0|Erianin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Erianin |
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| CAS Number | 95041-90-0 | Molecular Weight | 318.364 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 439.1±40.0 °C at 760 mmHg |
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| Molecular Formula | C18H22O5 | Melting Point | / |
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| MSDS | / | Flash Point | 219.4±27.3 °C |
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Names
| Name | 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol |
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| Synonym | More Synonyms |
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Erianin BiologicalActivity
| Description | Erianin, often used as an antipyretic and analgesic agent, could inhibit IDO-induced tumor angiogenesis. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>CancerResearch Areas >>Neurological DiseaseNatural Products >>Others |
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| In Vitro | Erianin is often used as antipyretic and analgesic agent. Erianin belongs to bibenzyl derivatives in structure, with the activity of anti-virus, anti-bacterial, as well as anti-benign prostatic hyperplasia. Erianin has obvious damage on 2LL-IDO cells, Erianin basically has no cytotoxicity on human normal liver cell line L02, and cell viability is maintained at around 85%[1]. Erianin inhibits the growth of HeLa cells and induces apoptosis in a dose‑ and time‑dependent manner, inducing cell cycle arrest at the G2/M stage. Erianin treatment also increases the expression of Bax and caspase‑3, but decreases levels of Bcl‑2 and phosphorylated‑ERK1/2[2]. |
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| References | [1]. Su C, et al. Erianin inhibits indoleamine 2, 3-dioxygenase -induced tumor angiogenesis. Biomed Pharmacother. 2017 Apr;88:521-528. [2]. Li M, et al. Erianin inhibits human cervical cancer cell through regulation of tumor protein p53 via the extracellular signal-regulated kinase signaling pathway. Oncol Lett. 2018 Oct;16(4):5006-5012. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 439.1±40.0 °C at 760 mmHg |
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| Molecular Formula | C18H22O5 |
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| Molecular Weight | 318.364 |
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| Flash Point | 219.4±27.3 °C |
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| Exact Mass | 318.146729 |
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| PSA | 57.15000 |
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| LogP | 3.11 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.554 |
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| InChIKey | UXDFUVFNIAJEGM-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CCc2cc(OC)c(OC)c(OC)c2)cc1O |
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Synonyms
| Phenol, 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]- |
| Dihydrocombretatastin A-4 |
| Erianin |
| 2-methoxy-5-[2-(3,4,5-trimethoxyphenyl)-ethyl]-phenol |
| 5-(3,4,5-trimethoxyphenethyl)-2-methoxyphenol |
| 2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]phenol |
| (E)-2-methoxy-5-(3,4,5-trimethoxyphenylethyl)phenol |
| 3-hydroxy-3',4',4,5'-tetramethoxybibenzyl |
| 2-Methoxy-5-[2-(3,4,5-trimethoxyphenyl)ethyl]benzolol |
