CAS 145-42-6|Sodium taurocholate
Introduction：Basic information about CAS 145-42-6|Sodium taurocholate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sodium taurocholate | ||
|---|---|---|---|
| CAS Number | 145-42-6 | Molecular Weight | 537.685 |
| Density | / | Boiling Point | / |
| Molecular Formula | C26H44NNaO7S | Melting Point | 230 °C |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | sodium taurocholate |
|---|---|
| Synonym | More Synonyms |
Sodium taurocholate BiologicalActivity
| Description | Taurocholic acid sodium (Sodium taurocholate; N-Choloyltaurine sodium) has marked bioactive effects such as an inhibitory potential against hepatic artery ligation induced biliary damage by upregulation of VEGF-A expression. Immunoregulation effect[1]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Protein Tyrosine Kinase/RTK >>VEGFR |
| Target | Microbial Metabolite Human Endogenous Metabolite |
| References | [1]. Caiyun Wang, et al. Effects of taurocholic acid on immunoregulation in mice. Int Immunopharmacol. 2013 Feb;15(2):217-22. |
Chemical & Physical Properties
| Melting Point | 230 °C |
|---|---|
| Molecular Formula | C26H44NNaO7S |
| Molecular Weight | 537.685 |
| Exact Mass | 537.273621 |
| PSA | 155.37000 |
| LogP | 3.49720 |
| Index of Refraction | 23 ° (C=3, H2O) |
| InChIKey | JAJWGJBVLPIOOH-XVEATTITSA-M |
| SMILES | CC(CCC(=O)NCCS(=O)(=O)[O-])C1CCC2C3C(O)CC4CC(O)CCC4(C)C3CC(O)C12C.[Na+] |
| Water Solubility | > 250 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - other changes
MUTATION DATA - TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80529 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80529 No. of Facilities: 52 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 741 (estimated) No. of Female Employees: 544 (estimated)
- TEST SYSTEM :
- Rodent - rat
- DOSE/DURATION :
- 1 gm/kg
- REFERENCE :
- JJCREP Japanese Journal of Cancer Research. (Elsevier Science Pub. BV, POB 211, 1000 AE Amsterdam, Netherlands) V.76- 1985- Volume(issue)/page/year: 78,32,1987 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 80529 No. of Facilities: 126 (estimated) No. of Industries: 3 No. of Occupations: 7 No. of Employees: 3026 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 80529 No. of Facilities: 52 (estimated) No. of Industries: 1 No. of Occupations: 2 No. of Employees: 741 (estimated) No. of Female Employees: 544 (estimated)
Safety Information
| Risk Phrases | R36/37/38 |
|---|---|
| Safety Phrases | S26-S36/37/39-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | WX0400000 |
Articles105
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Synonyms
| Taurine, N-choloyl-, monosodium salt |
| monosodium N-choloyltaurinate |
| sodium N-choloyltaurinate |
| Sodium 2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethanesulfonate |
| MFCD00013050 |
| ethanesulfonic acid, 2-[[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1) |
| Taurocholic Acid Sodium Salt from Bovine Bile |
| froM Bovine Bile |
| taurocholatesodiumsalt |
| Sodium 2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate |
| Ethanesulfonic acid, 2-[[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino]-, sodium salt (1:1) |
| taurocholic acid sodium salt |
| Sodium taurocholate |
| taurocholatesodium |
| Bile Salts (10 g) |
| TAUROCHOLIC ACID NA-SALT |
| 2-{[(3α,5β,7α,8ξ,12α)-3,7,12-Trihydroxy-24-oxocholan-24-yl]amino}éthanesulfonate de sodium |
| taurocholate sodium |
| taurocholate sodiuM sal |
| Natrium-2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethylhexadecahydro-1H-cyclopenta[a]phenanthren-17-yl]pentanoyl}amino)ethansulfonat |
| Sodium Taurocholate from Bovine Bile |
| Natrium-2-{[(3α,5β,7α,8ξ,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethansulfonat |
| Taurocholic acid |
| Monosodium 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)ethanesulfonate |
| EINECS 205-653-7 |
| Sodium 2-{[(3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl]amino}ethanesulfonate |
| taurocholate sodium salt |
| taurochlolic acid sodium salt |
| Ethanesulfonic acid, 2-(((3α,5β,7α,12α)-3,7,12-trihydroxy-24-oxocholan-24-yl)amino)-, monosodium salt |
| Taurocholic sodium |
| 2-({(4R)-4-[(3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-Trihydroxy-10,13-diméthylhexadécahydro-1H-cyclopenta[a]phénanthrén-17-yl]pentanoyl}amino)éthanesulfonate de sodium |
| Taurine, N-choloyl-, sodium salt |
| Sodium taurocholate hydrate |
