CAS 153-98-0|Serotonin hydrochloride

Introduction：Basic information about CAS 153-98-0|Serotonin hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Serotonin hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Customs
6. Articles41
7. Synonyms

Common Name	Serotonin hydrochloride
CAS Number	153-98-0	Molecular Weight	212.676
Density	/	Boiling Point	416.1ºC at 760 mmHg
Molecular Formula	C₁₀H₁₃ClN₂O	Melting Point	149-154 °C(lit.)
MSDS	ChineseUSA	Flash Point	205.4ºC
Symbol	GHS07	Signal Word	Warning

Names

Name	Serotonin hydrochloride
Synonym	More Synonyms

Serotonin hydrochloride BiologicalActivity

Description	Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride is also a catechol O-methyltransferase (COMT) inhibitor with a Ki of 44 μM.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>5-HT ReceptorSignaling Pathways >>Neuronal Signaling >>5-HT ReceptorSignaling Pathways >>Metabolic Enzyme/Protease >>COMTSignaling Pathways >>Neuronal Signaling >>COMTResearch Areas >>Neurological Disease
Target	5-HT receptor[1] Ki: 44 μM (COMT)[1]
In Vitro	Serotonin hydrochloride is a monoamine neurotransmitter in the CNS and an endogenous 5-HT receptor agonist. Serotonin hydrochloride also inhibits catechol O-methyltransferase (COMT), an enzyme that contributes to modultion the perception of pain, via non-competitive binding to the site bound by catechol substrates with a binding affinity comparable to the binding affinity of catechol itself (Ki= 44 μM). Results show that addition of 100 μM of Serotonin hydrochloride decreases the reaction velocity of COMT[1].
In Vivo	Serotonin hydrochloride produces robust hypersensitivity compare to saline-treated controls (p<0.001)[1]. A significant increase in colonic 5-HT content is observed in IL-13-/- mice receiving Serotonin hydrochloride compare to IL-13-/- receiving vehicle following induction of DSS colitis[2].
Cell Assay	For macrophage culture, peritoneal cavity cells are collected from WT and IL-13-/- mice with or without dextran sodium sulfate (DSS) treatment and cultured. Cells are plated at a concentration of 3.0×106 cells per millilitre, and treated with either lipopolysaccharides (LPS); (100 ng/mL) or Serotonin hydrochloride (10-10 M) for 24 hours. The culture supernatant are collected and stored in -80°C until determination of cytokine levels using protein array system[2].
Animal Admin	Dextran sodium sulfate (DSS) colitis is induced by orally administering 5% DSS in drinking water for 5 days. In a separate experiment, IL-13-/- mice are injected subcutaneously with 100 mg/kg of Serotonin hydrochloride (5-HTP) twice daily for 8 days beginning 3 days prior to induction of DSS colitis; whereas, the control IL-13-/- mice receive saline as vehicle. Animals are anaesthetized prior to euthanization via cervical dislocation at the conclusion of each experiment or if they reach a predetermined end point (ie, loss of ≥20% body weight and/or significant deterioration of body condition)[2].
References	[1]. Tsao D, et al. Serotonin-induced hypersensitivity via inhibition of catechol O-methyltransferase activity. Mol Pain. 2012 Apr 13;8:25. [2]. Shajib MS, et al. Interleukin 13 and serotonin: linking the immune and endocrine systems in murine models of intestinal inflammation. PLoS One. 2013 Aug 28;8(8):e72774.

Chemical & Physical Properties

Boiling Point	416.1ºC at 760 mmHg
Melting Point	149-154 °C(lit.)
Molecular Formula	C₁₀H₁₃ClN₂O
Molecular Weight	212.676
Flash Point	205.4ºC
Exact Mass	212.071640
PSA	62.04000
LogP	2.87700
Vapour Pressure	1.63E-07mmHg at 25°C
InChIKey	MDIGAZPGKJFIAH-UHFFFAOYSA-N
SMILES	Cl.NCCc1c[nH]c2ccc(O)cc12
Storage condition	2-8°C
Stability	Stable, but light sensitive and hygroscopic. Incompatible with strong oxidizing agents.
Water Solubility	soluble

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H302-H312-H315-H319-H332-H335
Precautionary Statements	P261-P280-P305 + P351 + P338
Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xn:Harmful;
Risk Phrases	R20/21/22;R36/37/38
Safety Phrases	S22-S26-S36
RIDADR	UN2811
WGK Germany	3
RTECS	NM2571000
Packaging Group	III
Hazard Class	6.1
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles41

Chemical genetics reveals a complex functional ground state of neural stem cells.

Nat. Chem. Biol. 3(5) , 268-273, (2007)

The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain canc...

Simultaneous determination of the repertoire of classical neurotransmitters released from embryonal carcinoma stem cells using online microdialysis coupled with hydrophilic interaction chromatography–tandem mass spectrometry

Anal. Chim. Acta 849 , 70-9, (2014)

[Display omitted]

Evaluation of thein vitro/in vivodrug interaction potential of BST204, a purified dry extract of ginseng, and its four bioactive ginsenosides through cytochrome P450 inhibition/induction and UDP-glucuronosyltransferase inhibition

Food Chem. Toxicol. 68 , 117-27, (2014)

• BST204 is a purified dry extract of ginseng containing high amounts of Rh2 and Rg3. • BST204 had only weak inhibitory effects on nine CYPs and five UGTs. • It is unlikely that BST204 alter pharmacok...

Synonyms

3-(2-aminoethyl)-1H-indol-5-ol,hydrochloride

3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride

3-(2-Aminoethyl)-5-hydroxyindole hydrochloride,5-HT,5-Hydroxytryptamine hydrochloride

5-hydroxytryptamine hydrochloride

Serotonin HCl

1H-Indol-5-ol, 3-(2-aminoethyl)-, hydrochloride (1:1)

3-(2-Aminoethyl)-1H-indol-5-ol hydrochloride (1:1)

EINECS 244-464-4

MFCD00012686

5-Hydroxytryptamine HCl

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