Introduction：Basic information about CAS 932-53-6|6-Azathymine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 6-Azathymine |
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| CAS Number | 932-53-6 | Molecular Weight | 127.101 |
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| Density | 1.7±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C4H5N3O2 | Melting Point | 210-212°C |
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| MSDS | / | Flash Point | / |
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Names
| Name | 6-methyl-2H-1,2,4-triazine-3,5-dione |
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| Synonym | More Synonyms |
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6-Azathymine BiologicalActivity
| Description | 6-Azathymine, a 6-nitrogen analog of thymine, is a potent D-3-aminoisobutyrate-pyruvate aminotransferase inhibitor. 6-Azathymine inhibits the biosynthesis of DNA, and has antibacterial and antiviral activities[1][2][3][4]. |
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| Related Catalog | Signaling Pathways >>Anti-infection >>Influenza VirusResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>Nucleoside Antimetabolite/AnalogSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | 6-Azathymine is a competitive antagonist of the growth of Streptococcus faecalis (8043) and several other strains of microorganisms. Studies of the mechanism of action of 6-Azathymine reveal that S. faecalis can convert the analog to the corresponding deoxyriboside, azathymidine[2]. |
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| References | [1]. N Tamaki, et al. Purification, Characterization and Inhibition of D-3-aminoisobutyrate Aminotransferase From the Rat Liver. Eur J Biochem. 1990 Apr 20;189(1):39-45. [2]. W H PRUSOFF, et al. Effect of the Deoxyriboside of 6-azathymine (Azathymidine) on the Biosynthesis of Deoxyribonucleic Acid by Bone Marrow and Neoplastic Cells (In Vitro). Biochim Biophys Acta. 1956 Apr;20(1):209-14. [3]. R A GAITO, et al. Studies on the Metabolism of Thymine and 6-azathymine. Biochem Pharmacol. Apr-May 1962;11:323-36. [4]. B. Gabrielsen, et al. In vitro and in vivo antiviral (RNA) evaluation of orotidine 51-monophosphatedecarboxylase inhibitors and analogues including 6-azauridine-51-(ethylmethoxyalaninyl)phosphate (a 51-monophosphate prodrug). Antiviral Chemistry & Chemotherapy (1994) 5(4), 209-220. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Melting Point | 210-212°C |
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| Molecular Formula | C4H5N3O2 |
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| Molecular Weight | 127.101 |
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| Exact Mass | 127.038177 |
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| PSA | 78.61000 |
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| LogP | -2.05 |
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| Index of Refraction | 1.692 |
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| InChIKey | XZWMZFQOHTWGQE-UHFFFAOYSA-N |
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| SMILES | Cc1n[nH]c(=O)[nH]c1=O |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- XY8050000
- CHEMICAL NAME :
- as-Triazine-3,5(2H,4H)-dione, 6-methyl-
- CAS REGISTRY NUMBER :
- 932-53-6
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C4-H5-N3-O2
- MOLECULAR WEIGHT :
- 127.12
- WISWESSER LINE NOTATION :
- T6NMVMVJ F1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 1800 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage)
- REFERENCE :
- AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 95,123,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: AD277-689
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Safety Information
| Safety Phrases | S22-S24/25 |
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| RTECS | XY8050000 |
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| HS Code | 2933699090 |
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Customs
| HS Code | 2933699090 |
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| Summary | 2933699090 other compounds containing an unfused triazine ring (whether or not hydrogenated) in the structure。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:20.0% |
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Synonyms
| 6-Methyl-2H-[1,2,4]triazin-3,5-dion |
| USAF CB-28 |
| 1,2,4-triazine-3,5-diol, 6-methyl- |
| Azathymine |
| 6-methyl-2H-[1,2,4]triazine-3,5-dione |
| Azathymine,6 |
| 6-azathymine |
| 1,2,4-Triazine-3,5(2H,4H)-dione,6-methyl |
| 6-methyl-2H-[1,2,4]triazin-3,5-dione |
| 6-methyl-2,3,4,5-tetrahydro-1,2,4-triazine-3,5-dione |
| 6-Methyl-1,2,4-triazine-3,5(2H,4H)-dione |
| 6-methyl-1,2,4-triazine-3,5-diol |
| 5-Methyl-6-azauracil |
| MFCD00006457 |
| 1,2,4-Triazine-3,5(2H,4H)-dione, 6-methyl- |
| EINECS 213-253-9 |
