CAS 676596-65-9|1-Azakenpaullone
| Common Name | 1-Azakenpaullone | ||
|---|---|---|---|
| CAS Number | 676596-65-9 | Molecular Weight | 328.163 |
| Density | 1.7±0.1 g/cm3 | Boiling Point | 648.8±50.0 °C at 760 mmHg |
| Molecular Formula | C15H10BrN3O | Melting Point | >290ºC (dec.) |
| MSDS | ChineseUSA | Flash Point | 346.2±30.1 °C |
Names
| Name | 1-Azakenpaullone |
|---|---|
| Synonym | More Synonyms |
1-Azakenpaullone BiologicalActivity
| Description | 1-Azakenpaullone (1-Akp) is a highly selective and ATP-competitive inhibitor of glycogen synthase kinase-3 β (GSK-3β), with an IC50 value of 18 nM[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>GSK-3Research Areas >>Metabolic DiseaseSignaling Pathways >>PI3K/Akt/mTOR >>GSK-3 |
| Target | GSK-3β:18 nM (IC50) CDK1/cyclin B:2 μM (IC50) CDK5/p25:4.2 μM (IC50) |
| References | [1]. Kunick C, et al. 1-Azakenpaullone is a selective inhibitor of glycogen synthase kinase-3 beta. Bioorg Med Chem Lett. 2004 Jan 19;14(2):413-6. |
Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
|---|---|
| Boiling Point | 648.8±50.0 °C at 760 mmHg |
| Melting Point | >290ºC (dec.) |
| Molecular Formula | C15H10BrN3O |
| Molecular Weight | 328.163 |
| Flash Point | 346.2±30.1 °C |
| Exact Mass | 327.000702 |
| PSA | 57.78000 |
| LogP | 3.19 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.740 |
| InChIKey | NTSBZVCEIVPKBJ-UHFFFAOYSA-N |
| SMILES | O=C1Cc2c([nH]c3ccc(Br)cc23)-c2ncccc2N1 |
| Storage condition | -20°C Freezer |
| Water Solubility | DMSO: >10mg/mL |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|
Articles3
More Articles| Efficient definitive endoderm induction from mouse embryonic stem cell adherent cultures: a rapid screening model for differentiation studies. Stem Cell Res. 12(1) , 166-77, (2014) Definitive endoderm (DE) differentiation from mouse embryonic stem cell (mESC) monolayer cultures has been limited by poor cell survival or low efficiency. Recently, a combination of TGFβ and Wnt acti... | |
| WNT3 and membrane-associated β-catenin regulate trophectoderm lineage differentiation in human blastocysts. Mol. Hum. Reprod. 21 , 711-22, (2015) WNT/β-catenin signaling has been described as a crucial regulator of embryonic stem cells and embryogenesis. However, little is known on its role during human preimplantation embryo development, besid... | |
| GSK3β-dependent phosphorylation alters DNA binding, transactivity and half-life of the transcription factor USF2. PLoS ONE 9(9) , e107914, (2014) The upstream stimulatory factor 2 (USF2) is a regulator of important cellular processes and is supposed to have also a role during tumor development. However, the knowledge about the mechanisms that c... |
Synonyms
| Pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one, 9-bromo-7,12-dihydro- |
| azakenpaullone |
| 9-Bromo-7,12-dihydropyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one |
| 9-Bromo-7,12-dihydro-pyrido[3',2':2,3]azepino[4,5-b]indol-6(5H)-one |
| 1-Azakenpaullone |
| Kinome_3492 |
| HMS3229B07 |
