CAS 53847-30-6|2-arachidonoylglycerol
| Common Name | 2-arachidonoylglycerol | ||
|---|---|---|---|
| CAS Number | 53847-30-6 | Molecular Weight | 378.545 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 508.6±50.0 °C at 760 mmHg |
| Molecular Formula | C23H38O4 | Melting Point | / |
| MSDS | USA | Flash Point | 163.0±23.6 °C |
| Symbol | GHS02, GHS07 | Signal Word | Danger |
Names
| Name | 2-arachidonoylglycerol |
|---|---|
| Synonym | More Synonyms |
2-arachidonoylglycerol BiologicalActivity
| Description | 2-Arachidonoylglycerol is a second endogenous cannabinoid ligand in the central nervous system. |
|---|---|
| Related Catalog | Signaling Pathways >>GPCR/G Protein >>Cannabinoid ReceptorResearch Areas >>Neurological DiseaseNatural Products >>Others |
| Target | Human Endogenous Metabolite |
| In Vitro | 2-Arachidonylglycerol (2-AG) is a cannabinoid ligand isolated from intestinal tissue. 2-Arachidonoylglycerol activates neuronal cannabinoid receptors as a full agonist, and prevents the induction of long-term potentiation at CA3-CA1 synapses. 2-Arachidonoylglycerol binds to cannabinoid receptors and exerts several effects typical of cannabinoid drugs[1]. |
| References | [1]. Stella N, et al. A second endogenous cannabinoid that modulates long-term potentiation. Nature. 1997 Aug 21;388(6644):773-8. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 508.6±50.0 °C at 760 mmHg |
| Molecular Formula | C23H38O4 |
| Molecular Weight | 378.545 |
| Flash Point | 163.0±23.6 °C |
| Exact Mass | 378.277008 |
| PSA | 66.76000 |
| LogP | 6.24 |
| Vapour Pressure | 0.0±3.0 mmHg at 25°C |
| Index of Refraction | 1.508 |
| InChIKey | RCRCTBLIHCHWDZ-DOFZRALJSA-N |
| SMILES | CCCCCC=CCC=CCC=CCC=CCCCC(=O)OC(CO)CO |
| Storage condition | −20°C |
Safety Information
| Symbol | GHS02, GHS07 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H225-H302 + H312 + H332-H319 |
| Precautionary Statements | P210-P261-P280-P305 + P351 + P338-P370 + P378-P403 + P235 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xn: Harmful;F: Flammable; |
| Risk Phrases | R11 |
| Safety Phrases | S26-S36/37 |
| RIDADR | UN 1648 3/PG 2 |
| WGK Germany | 2 |
| HS Code | 2916190090 |
Customs
| HS Code | 2916190090 |
|---|---|
| Summary | 2916190090 unsaturated acyclic monocarboxylic acids, their anhydrides, halides, peroxides, peroxyacids and their derivatives。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:6.5%。general tariff:30.0% |
Articles18
More Articles| The human serum metabolome. PLoS ONE 6(2) , e16957, (2011) Continuing improvements in analytical technology along with an increased interest in performing comprehensive, quantitative metabolic profiling, is leading to increased interest pressures within the m... | |
| Identification of palmitoyl protein thioesterase 1 in human THP1 monocytes and macrophages and characterization of unique biochemical activities for this enzyme. Biochemistry 52(43) , 7559-74, (2013) The profiles of serine hydrolases in human and mouse macrophages are similar yet different. For instance, human macrophages express high levels of carboxylesterase 1 (CES1), whereas mouse macrophages ... | |
| Effect of selective inhibition of monoacylglycerol lipase (MAGL) on acute nausea, anticipatory nausea, and vomiting in rats and Suncus murinus. Psychopharmacol. Ser. 232(3) , 583-93, (2015) To determine the role of the endocannabinoid, 2-arachodonyl glycerol (2-AG), in the regulation of nausea and vomiting.We evaluated the effectiveness of the potent selective monoacylglycerol lipase (MA... |
Synonyms
| 1,3-Dihydroxy-2-propanyl (5Z,8Z,11Z,14Z)-5,8,11,14-icosatetraenoate |
| 1,3-Dihydroxypropan-2-yl (5Z,8Z,11Z,14Z)-icosa-5,8,11,14-tetraenoate |
| MFCD01862600 |
| 5,8,11,14-Eicosatetraenoic acid, 2-hydroxy-1-(hydroxymethyl)ethyl ester, (5Z,8Z,11Z,14Z)- |
| 2-arachidonoylglycerol |
| 2-Arachidonyl Glycerol |
| EINECS 200-835-2 |
| 2-arachidonoyl glycerol |
