Introduction：Basic information about CAS 108930-17-2|H7, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
PKC-IN-5 (compound H-7) is a potent PKC (protein kinase C) inhibitor. At 100 μM, PKC-IN-5 completely inhibits both TPA (skin tumour promoter, 12-O-tetradecanoylphorbol-13-acetate) and phospholipase C-induced ODC (ornithine decarboxylase)[1].
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Signaling Pathways >>Epigenetics >>PKCResearch Areas >>CancerSignaling Pathways >>TGF-beta/Smad >>PKC
References
[1]. Fischer SM, et al. Mediation of phorbol ester-induced oxidant generation in murine epidermal cells by protein kinase C. Toxicol In Vitro. 1989;3(3):195-9.
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PKC enhances the capacity for secretion by rapidly recruiting covert voltage-gated Ca2+ channels to the membrane.
J. Neurosci. 35(6) , 2747-65, (2015)
It is unknown whether neurons can dynamically control the capacity for secretion by promptly changing the number of plasma membrane voltage-gated Ca(2+) channels. To address this, we studied peptide r...
