Introduction：Basic information about CAS 14325-05-4|Tin-protoporphyrin IX, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tin-protoporphyrin IX |
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| CAS Number | 14325-05-4 | Molecular Weight | 754.290 |
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| Density | / | Boiling Point | 849.3±75.0 °C at 760 mmHg |
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| Molecular Formula | C34H32Cl2N4O4Sn | Melting Point | / |
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| MSDS | / | Flash Point | 467.5±37.1 °C |
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Names
| Name | tin protoporphyrin IX dichloride |
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| Synonym | More Synonyms |
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Tin-protoporphyrin IX BiologicalActivity
| Description | Tin-protoporphyrin IX (SnPPIX) is a potent Heme oxygenase-1 (HO-1) inhibitor. Tin-protoporphyrin IX (SnPPIX) sensitizes pancreatic ductal adenocarcinoma (PDAC) tumors to chemotherapy in mice model[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| Target | IC50: Heme oxygenase-1 (HO-1)[1] |
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| In Vitro | Tin-protoporphyrin IX (SnPPIX)(20 μM, 50 μM; 24 hours) significantly suppressed the proliferation of Capan-1 and CD18/HPAF cells. In contrast, SnPPIX has no significant effect on PDAC cells proliferation at all exposures except at 50 μM[1]. Cell Viability Assay[1] Cell Line: Capan-1, CD18/HPAF, PDAC cells Concentration: 20 μM, 50 μM Incubation Time: 24 or 72 hours Result: Inhibited Capan-1 and CD18/HPAF cells proliferation and inhibits PDAC cells growth at 50μM. |
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| In Vivo | Tin-protoporphyrin IX (SnPPIX)(intraperitoneal injection; 5 mg/kg; at 0, 7, 15, and 20 days) alone or combines with Gemcitabine significantly reduced the weight of pancreatic tumors (P < 0.05), decreases metastasis and improved the efficacy of Gemcitabine treatment[1]. Animal Model: Male and female athymic nude mice with PDAC cell-derived xenograft tumors[1] Dosage: 5 mg/kg Administration: Intraperitoneal injection; at days 1, 4, 6, 8, 11, 13, 15, 18, and 20 Result: Inhibited tumor growth and sensitized tumors to chemotherapy (Gemcitabine). |
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| References | [1]. Abdalla MY,et al.Enhancing responsiveness of pancreatic cancer cells to gemcitabine treatment under hypoxia by heme oxygenase-1 inhibition.Transl Res. 2019 May;207:56-69. |
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Chemical & Physical Properties
| Boiling Point | 849.3±75.0 °C at 760 mmHg |
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| Molecular Formula | C34H32Cl2N4O4Sn |
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| Molecular Weight | 754.290 |
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| Flash Point | 467.5±37.1 °C |
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| Exact Mass | 754.113586 |
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| PSA | 109.18000 |
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| LogP | 4.75380 |
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| Vapour Pressure | 0.0±3.3 mmHg at 25°C |
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Synonyms
| 3,3'-[(1Z,6Z,12Z,17Z)-22,22-Dichloro-15,20-diethyl-5,9,14,19-tetramethyl-21,23,24,25-tetraaza-22-stannahexacyclo[9.9.3.1.1.0.0]pentacosa-1,3(25),4,6,8,10,12,14,16(24),17,19-un 
decaene-4,10-diyl]dipropanoic acid |
| tin protophorphyrin |
