CAS 130465-39-3|A-68930 hydrochloride
| Common Name | A-68930 hydrochloride | ||
|---|---|---|---|
| CAS Number | 130465-39-3 | Molecular Weight | 307.77200 |
| Density | / | Boiling Point | / |
| Molecular Formula | C16H18ClNO3 | Melting Point | 250ºC |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | A-68930 hydrochloride |
|---|---|
| Synonym | More Synonyms |
A-68930 hydrochloride BiologicalActivity
| Description | A68930 hydrochloride, as a dopamine D1 receptor agonist, can be used for the research of bronchiectasis[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>GPCR/G Protein >>Dopamine ReceptorSignaling Pathways >>Neuronal Signaling >>Dopamine Receptor |
| Target | D1 Receptor |
| In Vitro | A68930 hydrochloride (1 μM; 5-60 minutes; 16HBE14o- or NCI-H292 cells) significantly increases phosphorylation of cAMP response element binding (CREB) protein[1]. A68930 hydrochloride (1 μM; 48 hours; NCI-H292 cells) induces MUC5AC mRNA expression and increases the mRNA data of MUC5AC and MUC5AC protein expression[1]. A68930 hydrochloride (1 μM; 20 minutes; NCI-H292 cells) significantly increases intracellular cAMP levels[1]. Western Blot Analysis[1] Cell Line: 16HBE14o- or NCI-H292 cells Concentration: 1 μM Incubation Time: 5~60 minutes Result: Significantly increased phosphorylation of CREB. RT-PCR[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: Induced MUC5AC mRNA expression. Immunofluorescence[1] Cell Line: NCI-H292 cells Concentration: 1 μM Incubation Time: 48 hours Result: The mRNA data of MUC5AC, MUC5AC protein expression were increased. |
| References | [1]. Matsuyama N, et al. The dopamine D1 receptor is expressed and induces CREB phosphorylation and MUC5AC expression in human airway epithelium. Respir Res. 2018;19(1):53. Published 2018 Apr 2. |
Chemical & Physical Properties
| Melting Point | 250ºC |
|---|---|
| Molecular Formula | C16H18ClNO3 |
| Molecular Weight | 307.77200 |
| Exact Mass | 307.09800 |
| PSA | 75.71000 |
| LogP | 3.91390 |
| InChIKey | PQPGUUQPTSMLKU-YYLIZZNMSA-N |
| SMILES | Cl.NCC1OC(c2ccccc2)Cc2c1ccc(O)c2O |
| Storage condition | -20°C |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Safety Phrases | 22-24/25 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2932999099 |
Customs
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles3
More Articles| A-68930, a novel, potent dopamine D1 receptor agonist: a microstructural analysis of its effects on feeding and other behaviour in the rat. Behav. Pharmacol. 5 , 210-218 , (1994) A-68930 [1R, 3S)-1-aminomethyl-5,6-dihydroxy-3-phenylisochroman HCI] is a novel, potent and selective dopamine D1 receptor agonist. Previous reports have shown that the selective D1 partial agonist, S... | |
| Sedative effects of the dopamine D1 receptor agonist A 68930 on rat open-field behavior. Neuroreport 11 , 1269-1279, (2000) The present results demonstrate sedative effects of the DA D1 receptor agonist A 68930 (0.9-15 micromol kg(-1), s.c.) on rat spontaneous locomotor activity in an open field. The effects were particula... | |
| A68930: a potent and specific agonist for the D-1 dopamine receptor. Am. J. Hypertens. 3 , 40S-42S, (1990) A68930 (5,6-dihydroxy-3-phenyl-1-aminomethyl-isochroman) is a potent (EC50 = 2.5 nmol/L) partial agonist at the D-1 dopamine receptor. In contrast, A68930 is a much weaker agonist (EC50 = 3,920 nmol/L... |
Synonyms
| cis-1-(Aminomethyl)-3-phenylisochroman-5,6-diol hydrochloride |
| (1R,3S)-1-(aminomethyl)-3-phenyl-3,4-dihydro-1H-isochromene-5,6-diol,hydrochloride |
