Introduction：Basic information about CAS 115199-84-3|ICI 199,441 hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | ICI 199,441 hydrochloride |
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| CAS Number | 115199-84-3 | Molecular Weight | 427.80 |
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| Density | / | Boiling Point | 532.8ºC at 760mmHg |
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| Molecular Formula | C21H25Cl3N2O | Melting Point | / |
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| MSDS | / | Flash Point | 276ºC |
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Names
| Name | ICI 199,441 hydrochloride,2-(3,4-Dichlorophenyl)-N-methyl-N-[(1S)-1-phenyl-2-(1-pyrrolidinyl)ethyl]acetamidehydrochloride |
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| Synonym | More Synonyms |
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ICI 199,441 hydrochloride BiologicalActivity
| Description | ICI 199441 is a potent and selective κ-opioid receptor agonist. ICI 199441 can improve heart resistance to ischemia/reperfusion[1]. |
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| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Opioid ReceptorSignaling Pathways >>Neuronal Signaling >>Opioid Receptor |
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| In Vivo | ICI 199441 (Wistar rats, 0.1 mg/kg, IV, once) administered 15 min before ischemia produces a potent antiarrhythmic effect[1]. |
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| References | [1]. Tsibulnikov SY, et al. Prospects of Using of κ-Opioid Receptor Agonists U-50,488 and ICI 199,441 for Improving Heart Resistance to Ischemia/Reperfusion. Bull Exp Biol Med. 2015;159(6):718-721. |
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Chemical & Physical Properties
| Boiling Point | 532.8ºC at 760mmHg |
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| Molecular Formula | C21H25Cl3N2O |
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| Molecular Weight | 427.80 |
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| Flash Point | 276ºC |
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| Exact Mass | 426.10300 |
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| PSA | 23.55000 |
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| LogP | 5.57130 |
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| Vapour Pressure | 1.97E-11mmHg at 25°C |
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| InChIKey | VFLWVWZSDBTGQJ-VEIFNGETSA-N |
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| SMILES | CN(C(=O)Cc1ccc(Cl)c(Cl)c1)C(CN1CCCC1)c1ccccc1.Cl |
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Synonyms
| ici 199,441 |
| ici 199,441 hydrochloride |
