CAS 138199-51-6|(RS)-(Tetrazol-5-yl)glycine
Introduction：Basic information about CAS 138199-51-6|(RS)-(Tetrazol-5-yl)glycine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (RS)-(Tetrazol-5-yl)glycine | ||
|---|---|---|---|
| CAS Number | 138199-51-6 | Molecular Weight | 143.10400 |
| Density | 1.804 g/cm3 | Boiling Point | 447.1ºC at 760 mmHg |
| Molecular Formula | C3H5N5O2 | Melting Point | / |
| MSDS | / | Flash Point | 224.2ºC |
Names
| Name | 2-amino-2-(2H-tetrazol-5-yl)acetic acid |
|---|---|
| Synonym | More Synonyms |
(RS)-(Tetrazol-5-yl)glycine BiologicalActivity
| Description | (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a highly potent and selective N-methyl-D-aspartate (NMDA) receptor agonist[1]. (RS)-(Tetrazol-5-yl)glycine has EC50s of 99 nM, 1.7 μM for GluN1/GluN2D and GluN1/GluN2A, respectively[2]. (RS)-(Tetrazol-5-yl)glycine induces seizure responses and Fos in mice[3]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>iGluRResearch Areas >>Neurological DiseaseSignaling Pathways >>Membrane Transporter/Ion Channel >>iGluR |
| Target | EC50: 99 nM (GluN1/GluN2D) and 1.7 μM (GluN1/GluN2A)[1] |
| In Vitro | (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine) is a agonist of N-methyl-D-aspartate (NMDA) subtype of excitatory amino acid receptor. (RS)-(Tetrazol-5-yl)glycine displaces NMDA receptor binding to rat brain membranes as measured using [3H]CGS19755 (IC50=98 nM) and [3H]glutamate (IC50=36 nM) as ligands[1]. (RS)-(Tetrazol-5-yl)glycine does not appreciably inhibit the binding of D,L-alpha-[5-methyl-3H] amino-3-hydroxy-5-methylisoxazole-4-propionic acid (AMPA), [3H]kainate, or [3H]glycine (IC50s>30 μM)[1]. |
| In Vivo | (RS)-(Tetrazol-5-yl)glycine (D,L-(tetrazol-5-yl)glycine; 1.25, 1.5 mg/kg; IP) induces seizure responses and Fos in the NR1+/+ and NR1-/- mice[3]. (RS)-(Tetrazol-5-yl)glycine is a highly potent convulsant when given to neonatal rats (ED50=0.071 mg/kg; i.p.) [1]. Animal Model: C57BL/6 mice[3] Dosage: 1.25, 1.5 mg/kg Administration: IP Result: Induced seizure responses and Fos. |
| References | [1]. Schoepp DD, et al. D,L-(tetrazol-5-yl) glycine: a novel and highly potent NMDA receptor agonist. Eur J Pharmacol. 1991 Oct 15;203(2):237-43. [2]. Vance KM, et al. Ligand-specific deactivation time course of GluN1/GluN2D NMDA receptors. Nat Commun. 2011;2:294. [3]. Duncan GE, et al. Seizure responses and induction of Fos by the NMDA agonist (tetrazol-5-yl)glycine in a geneticmodel of NMDA receptor hypofunction. Brain Res. 2008 Jul 24;1221:41-8. |
Chemical & Physical Properties
| Density | 1.804 g/cm3 |
|---|---|
| Boiling Point | 447.1ºC at 760 mmHg |
| Molecular Formula | C3H5N5O2 |
| Molecular Weight | 143.10400 |
| Flash Point | 224.2ºC |
| Exact Mass | 143.04400 |
| PSA | 117.78000 |
| Vapour Pressure | 8.91E-09mmHg at 25°C |
| Index of Refraction | 1.669 |
| InChIKey | UKBRUIZWQZHXFL-UHFFFAOYSA-N |
| SMILES | NC(C(=O)O)c1nn[nH]n1 |
Synonyms
| Mepyramine maleate |
| Tetrazol-5-yl-gly |
| Tetrazolylglycine |
| Tet-glycine |
| 5-Tetrazolyl-glycine |
