CAS 88296-62-2|Transcainide

Introduction：Basic information about CAS 88296-62-2|Transcainide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Transcainide BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA

Common Name	Transcainide
CAS Number	88296-62-2	Molecular Weight	373.53200
Density	1.13g/cm3	Boiling Point	529.4ºC at 760 mmHg
Molecular Formula	C₂₂H₃₅N₃O₂	Melting Point	/
MSDS	/	Flash Point	274ºC

Names

Name	Transcainide

Transcainide BiologicalActivity

Description	Transcainide (R 54718) is an orally active antiarrhythmic agent[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others
References	[1]. R Stroobandt, Evaluation of the efficacy and tolerance of the antiarrhythmic agent transcainide (R 54718). Eur J Clin Pharmacol. 1987;32(5):449-56.

Chemical & Physical Properties

Density	1.13g/cm3
Boiling Point	529.4ºC at 760 mmHg
Molecular Formula	C₂₂H₃₅N₃O₂
Molecular Weight	373.53200
Flash Point	274ºC
Exact Mass	373.27300
PSA	55.81000
LogP	2.95250
Index of Refraction	1.58
InChIKey	MFKCGXDCHAFQQZ-RTBURBONSA-N
SMILES	Cc1cccc(C)c1NC(=O)C1(N(C)C)CCN(C2CCCCC2O)CC1

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: TM6060000

CHEMICAL NAME :: 4-Piperidinecarboxamide, 4-(dimethylamino)-N-(2,6-dimethylphenyl)-1-(2-hydroxy cyclohexyl)-, trans-(+-)-

CAS REGISTRY NUMBER :: 88296-62-2

LAST UPDATED :: 198910

DATA ITEMS CITED :: 4

MOLECULAR FORMULA :: C22-H35-N3-O2

MOLECULAR WEIGHT :: 373.60

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 4830 ug/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - ataxia Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 440 ug/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - effect, not otherwise specified Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - dyspnea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 1500 ug/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - hypermotility, diarrhea

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 440 ug/kg

TOXIC EFFECTS :: Behavioral - altered sleep time (including change in righting reflex) Gastrointestinal - hypermotility, diarrhea Gastrointestinal - nausea or vomiting

REFERENCE :: AIPTAK Archives Internationales de Pharmacodynamie et de Therapie. (Heymans Institute of Pharmacology, De Pintelaan 185, B-9000 Ghent, Belgium) V.4- 1898- Volume(issue)/page/year: 287,272,1987

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