Introduction：Basic information about CAS 89371-44-8|Imidaprilate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Imidaprilate |
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| CAS Number | 89371-44-8 | Molecular Weight | 377.39200 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C18H23N3O6 | Melting Point | 180-182ºC |
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| MSDS | / | Flash Point | / |
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Names
| Name | (4S)-3-[(2S)-2-[[(1S)-1-carboxy-3-phenylpropyl]amino]propanoyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid |
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| Synonym | More Synonyms |
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Imidaprilate BiologicalActivity
| Description | Imidaprilate is an active metabolite of TA-6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM, and is used in the research of hypertensive disease. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Angiotensin-converting Enzyme (ACE)Research Areas >>Cardiovascular Disease |
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| Target | IC50: 2.6 nM (ACE)[1] |
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| In Vitro | Imidaprilate (6366A) is an active metabolite of 6366, acts as a potent angiotensin converting enzyme (ACE) inhibitor, with an IC50 of 2.6 nM. Imidaprilate augments the bradykinin-induced contraction of guinea pig ileum, with AC50 of 1.7 nM[1]. |
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| In Vivo | Imidaprilate (≥0.2 mg/kg) inhibits angiotensin I (AT-I)-induced pressor response. TA-6366 lowers the blood pressure in two-kidney one-clip renal hypertensive rats at 0.5-2 mg/kg via oral administration, and in spontaneously hypertensive rats (SHRs) at 2 to 10 mg/kg[1]. |
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| References | [1]. Kubo M, et al. Pharmacological studies on (4S)-1-methyl-3-[(2S)-2-[N-((1S)-1-ethoxycarbonyl-3-phenylpropyl)amino] propionyl]-2-oxo-imidazolidine-4-carboxylic acid hydrochloride (TA-6366), a new ACE inhibitor: I. ACE inhibitory and anti-hypertensive activities. Jpn J Pharmacol. 1990 Jun;53(2):201-10. |
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Chemical & Physical Properties
| Melting Point | 180-182ºC |
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| Molecular Formula | C18H23N3O6 |
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| Molecular Weight | 377.39200 |
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| Exact Mass | 377.15900 |
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| PSA | 127.25000 |
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| LogP | 0.66440 |
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| InChIKey | VFAVNRVDTAPBNR-UBHSHLNASA-N |
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| SMILES | CC(NC(CCc1ccccc1)C(=O)O)C(=O)N1C(=O)N(C)CC1C(=O)O |
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Synonyms
| (4S)-3-<(2S)-2-<N-((1S)-1-carboxy-3-phenylpropyl)amino>propionyl>-1-methyl-2-oxoimidazolidine-4-carboxylic acid |
| (4S)-1-methyl-3-{(2S)-2-[N-((1S)-1-carboxy-3-phenylpropyl)amino]propionyl}-2-oxo-imidazolidine-4-carboxylic acid |
| UNII-WUU07Y30IA |
| Imidapril Diacid |
| Imidaprilat |
| (4S)-3-[(2S)-N-[(1S)-1-carboxy-3-phenylpropyl]alanyl]-1-methyl-2-oxoimidazolidine-4-carboxylic acid |
