Introduction：Basic information about CAS 104112-82-5|Phellodendrine chloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Phellodendrine chloride |
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| CAS Number | 104112-82-5 | Molecular Weight | 377.862 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C20H24ClNO4 | Melting Point | 249-251℃ (methanol ) |
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| MSDS | / | Flash Point | / |
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Names
| Name | Phellodendrine chloride |
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| Synonym | More Synonyms |
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Phellodendrine chloride BiologicalActivity
| Description | Phellodendrine chloride is a plant alkaloid found in Phellodendron amurense. Phellodendrine chloride suppresses the proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis [1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
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| References | [1]. Thu PM, et al. Phellodendrine chloride suppresses proliferation of KRAS mutated pancreatic cancer cells through inhibition of nutrients uptake via macropinocytosis. Eur J Pharmacol. 2019 May 5;850:23-34. |
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Chemical & Physical Properties
| Melting Point | 249-251℃ (methanol ) |
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| Molecular Formula | C20H24ClNO4 |
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| Molecular Weight | 377.862 |
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| Exact Mass | 377.139374 |
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| PSA | 58.92000 |
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| InChIKey | DGLDSNPMIYUWGN-OOJQBDKLSA-N |
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| SMILES | COc1cc2c(cc1O)CC1c3cc(O)c(OC)cc3CC[N+]1(C)C2.[Cl-] |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DR9848050
- CHEMICAL NAME :
- 13a-alpha-Berbinium, 2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride
- CAS REGISTRY NUMBER :
- 104112-82-5
- LAST UPDATED :
- 198909
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H24-N-O4.Cl
- MOLECULAR WEIGHT :
- 377.90
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 69500 ug/kg
- TOXIC EFFECTS :
- Behavioral - altered sleep time (including change in righting reflex) Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- NYKZAU Nippon Yakurigaku Zasshi. Japanese Journal of Pharmacology. (Nippon Yakuri Gakkai, c/o Kyoto Daigaku Igakubu Yakurigaku Kyoshitsu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.40- 1944- Volume(issue)/page/year: 58,138,1962
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Safety Information
Synonyms
| 6H-Dibenzo[a,g]quinolizinium, 5,8,13,13a-tetrahydro-2,11-dihydroxy-3,10-dimethoxy-7-methyl-, chloride, (13aS)- (1:1) |
| (13aS)-2,11-Dihydroxy-3,10-dimethoxy-7-methyl-5,8,13,13a-tetrahydro-6H-isoquinolino[3,2-a]isoquinolinium chloride |
