Introduction：Basic information about CAS 26833-86-3|Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate], including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cephalotaxine,3-[4-methyl (2R,3S)-2,3-dihydroxy-2-(3-methylbutyl)butanedioate] |
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| CAS Number | 26833-86-3 | Molecular Weight | 531.59500 |
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| Density | 1.35g/cm3 | Boiling Point | 632.5ºC at 760mmHg |
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| Molecular Formula | C28H37NO9 | Melting Point | 70.75°C |
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| MSDS | / | Flash Point | / |
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Names
| Name | Isoharringtonine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Isoharringtonine is a natural alkaloid that can be purified from Cephalotaxus koreana Nakai. Isoharringtonine can inhibit cancer cell proliferation and migration, and induce cancer cell apoptosis. Isoharringtonine can be used for the research of cancers[1][2]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| References | [1]. Lee JH, et al. Isoharringtonine Induces Apoptosis of Non-Small Cell Lung Cancer Cells in Tumorspheroids via the Intrinsic Pathway. Biomolecules. 2020 Nov 6;10(11):1521. [2]. Chen W, et al. Isoharringtonine inhibits breast cancer stem-like properties and STAT3 signaling. Biomed Pharmacother. 2018 Jul;103:435-442. |
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Chemical & Physical Properties
| Density | 1.35g/cm3 |
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| Boiling Point | 632.5ºC at 760mmHg |
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| Melting Point | 70.75°C |
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| Molecular Formula | C28H37NO9 |
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| Molecular Weight | 531.59500 |
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| Exact Mass | 531.24700 |
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| PSA | 123.99000 |
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| LogP | 1.98440 |
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| Vapour Pressure | 7.21E-17mmHg at 25°C |
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| Index of Refraction | 1.607 |
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| InChIKey | CAOHZEUEVKYHPF-XWHOPEMDSA-N |
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| SMILES | COC(=O)C(O)C(O)(CCC(C)C)C(=O)OC1C(OC)=CC23CCCN2CCc2cc4c(cc2C13)OCO4 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- NR2935500
- CHEMICAL NAME :
- Isoharringtonine
- CAS REGISTRY NUMBER :
- 26833-86-3
- LAST UPDATED :
- 198909
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C28-H37-N-O9
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 27950 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 14600 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 26110 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCISP* National Cancer Institute Screening Program Data Summary, Developmental Therapeutics Program. (Bethesda, MD 20205) Volume(issue)/page/year: JAN1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 13200 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JOETD7 Journal of Ethnopharmacology. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1979- Volume(issue)/page/year: 24,1,1988
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Synonyms
