CAS 2241-90-9|Cyclobuxine D

Introduction：Basic information about CAS 2241-90-9|Cyclobuxine D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Cyclobuxine D BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	Cyclobuxine D
CAS Number	2241-90-9	Molecular Weight	386.61400
Density	1.08g/cm3	Boiling Point	494.2ºC at 760mmHg
Molecular Formula	C₂₅H₄₂N₂O	Melting Point	236-238ºC
MSDS	/	Flash Point	53.5ºC

Names

Name	cyclobuxine-d
Synonym	More Synonyms

Cyclobuxine D BiologicalActivity

Description	Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].
Related Catalog	Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Inflammation/Immunology
References	[1]. . A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182. [2]. Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1): 103-109.

Description

Cyclobuxine D is a steroidal alkaloid extracted from Buxus microphylla. Cyclobuxine D has a significant bradycardic effect in the rat heart and an inhibitory action on acetylcholine and Ba++−induced contraction of the longitudinal muscle isolated from the rabbit jejunum[1][2].

Related Catalog

Signaling Pathways >>Neuronal Signaling >>mAChRSignaling Pathways >>GPCR/G Protein >>mAChRResearch Areas >>Inflammation/Immunology

References

[1]. . A. Eshonov, et al. Alkaloids of Buxus sempervirens, Crystal and Molecular Structure of Cyclobuxine-D and Imperialine. Chemistry of Natural Compounds. 12 January 2014. 49:11791182.

[2]. Kwon, Jun-Tack, et al. Effects of Cyclobuxine D on Drug-Induced Contractions of the Isolated Rat Uterine Muscle and Potassium-Activated Calcium Channels in an Intestinal Smooth Muscle. The Korean Journal of Pharmacology. 1988. 24 (1): 103-109.

Chemical & Physical Properties

Density	1.08g/cm3
Boiling Point	494.2ºC at 760mmHg
Melting Point	236-238ºC
Molecular Formula	C₂₅H₄₂N₂O
Molecular Weight	386.61400
Flash Point	53.5ºC
Exact Mass	386.33000
PSA	44.29000
LogP	4.90400
Vapour Pressure	7.7E-12mmHg at 25°C
Index of Refraction	1.561
InChIKey	BSNZFQANPMIOIU-WZBMPAQFSA-N
SMILES	C=C1C(NC)CCC23CC24CCC2(C)C(C(C)NC)C(O)CC2(C)C4CCC13

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GZ0590020

CHEMICAL NAME :: 9,19-Cyclo-5-alpha,9-beta-pregnan-16-alpha-ol, 14-methyl-3-beta,20-alpha-bis(methylamino)-4- methylene-

CAS REGISTRY NUMBER :: 2241-90-9

LAST UPDATED :: 198909

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C25-H42-N2-O

MOLECULAR WEIGHT :: 386.69

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 300 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: 85GDA2 "CRC Handbook of Antibiotic Compounds," Vols.1- , Berdy, J., Boca Raton, FL, CRC Press, 1980- Volume(issue)/page/year: 8(2),217,1982

Synonyms

cyclobuxine

cyclobuxine D

(3beta,5alpha,16alpha,20S)-14-Methyl-3,20-bis(methylamino)-4-methylene-9,19-cyclopregnan-16-ol

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