CAS 7619-53-6|Zuclomiphene (citrete)
Introduction：Basic information about CAS 7619-53-6|Zuclomiphene (citrete), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Zuclomiphene (citrete) | ||
|---|---|---|---|
| CAS Number | 7619-53-6 | Molecular Weight | 598.08300 |
| Density | / | Boiling Point | / |
| Molecular Formula | C32H36ClNO8 | Melting Point | / |
| MSDS | / | Flash Point | / |
Names
| Name | Clomiphene citrate, cis |
|---|---|
| Synonym | More Synonyms |
Zuclomiphene (citrete) BiologicalActivity
| Description | Zuclomiphene citrate is a cis isomer of Clomiphene citrate. Zuclomiphene citrate has an antiestrogenic effect and can inhibit the secretion of luteinizing hormone (LH) more than the trans isomer. Zuclomiphene citrate is also an orally active hypocholesterolemic agent[1][2][3][4]. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>Estrogen Receptor/ERRResearch Areas >>EndocrinologyResearch Areas >>Metabolic Disease |
| Target | Estrogen Receptor/ERR |
| References | [1]. Fontenot GK, et al. Differential effects of isomers of clomiphene citrate on reproductive tissues in male mice. BJU Int. 2016 Feb;117(2):344-50. [2]. Mikkelson TJ, et al. Single-dose pharmacokinetics of clomiphene citrate in normal volunteers. Fertil Steril. 1986 Sep;46(3):392-6. [3]. Sutherland RL. Estrogen antagonists in chick oviduct: antagonist activity of eight synthetic triphenylethylene derivatives and their interactions with cytoplasmic and nuclear estrogen receptors. Endocrinology. 1981 Dec;109(6):2061-8. [4]. Ramsey RB, et al. The biochemical and morphological response of hydrolytic enzymes in the developing brain to hypocholesterolemic agents. Acta Neuropathol. 1980;49(2):89-94. |
Chemical & Physical Properties
| Molecular Formula | C32H36ClNO8 |
|---|---|
| Molecular Weight | 598.08300 |
| Exact Mass | 597.21300 |
| PSA | 144.60000 |
| LogP | 5.31410 |
| InChIKey | PYTMYKVIJXPNBD-OQKDUQJOSA-N |
| SMILES | CCN(CC)CCOc1ccc(C(=C(Cl)c2ccccc2)c2ccccc2)cc1.O=C(O)CC(O)(CC(=O)O)C(=O)O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- male 60 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Paternal Effects - spermatogenesis (incl. genetic material, sperm morphology, motility, and count) Reproductive - Paternal Effects - prostate, seminal vesicle, Cowper's gland, accessory glands
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 11,23,1973
Synonyms
| cis-6,cis-11-Methyl-octadecadienoat |
| cis-clomiphene citrate |
| clomphencitrate |
| cis-cis-6,11-Octadecadiensaeuremethylester |
| Methyl-cis,cis-octadeca-6,11-dienoat |
| cis,cis-Octadeca-6,11-diensaeure-methylester |
| clomifen citrate |
| I-Dihydrocitrat |
| zuclomiphene citrate |
