Introduction：Basic information about CAS 483-15-8|Dihydroberberine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Dihydroberberine |
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| CAS Number | 483-15-8 | Molecular Weight | 337.369 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 557.8±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H19NO4 | Melting Point | 223-224ºC (dec.) |
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| MSDS | / | Flash Point | 170.7±27.3 °C |
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Names
| Name | 9,10-Dimethoxy-6,8-dihydro-5H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline |
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| Synonym | More Synonyms |
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Dihydroberberine BiologicalActivity
| Description | Dihydroberberine inhibits human ether-a-go-go-related gene (hERG) channels and remarkably reduces heat shock protein 90 (Hsp90) expression and its interaction with hERG. Dihydroberberine has anti-inflammatory, anti-atherosclerotic, hypolipidemic and antitumor activities[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>Metabolic Enzyme/Protease >>HSPResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Cell Cycle/DNA Damage >>HSPSignaling Pathways >>Membrane Transporter/Ion Channel >>Potassium Channel |
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| Target | HSP90 |
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| References | [1]. Yu D, et al. Inhibitory effects and mechanism of dihydroberberine on hERG channels expressed in HEK293 cells. PLoS One. 2017 Aug 1;12(8):e0181823. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 557.8±50.0 °C at 760 mmHg |
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| Melting Point | 223-224ºC (dec.) |
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| Molecular Formula | C20H19NO4 |
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| Molecular Weight | 337.369 |
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| Flash Point | 170.7±27.3 °C |
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| Exact Mass | 337.131409 |
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| PSA | 40.16000 |
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| LogP | 5.09 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.679 |
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| InChIKey | FZAGOOYMTPGPGF-UHFFFAOYSA-N |
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| SMILES | COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1=C2)OCO4 |
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| Storage condition | 2-8C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- DR9808500
- CHEMICAL NAME :
- Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-
- CAS REGISTRY NUMBER :
- 483-15-8
- BEILSTEIN REFERENCE NO. :
- 0344128
- LAST UPDATED :
- 199709
- DATA ITEMS CITED :
- 1
- MOLECULAR FORMULA :
- C20-H19-N-O4
- MOLECULAR WEIGHT :
- 337.40
- WISWESSER LINE NOTATION :
- T G6 E6 B665 EN SO UO FH TH&&T&&J HO1 IO1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 190 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory stimulation
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 15,486,1981
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Safety Information
Customs
| HS Code | 2934999090 |
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| Summary | 2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquinolino[3,2-a]isoquinoline |
| Dihydroberbine |
| 6H-1,3-Benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8-dihydro-9,10-dimethoxy- |
| 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline |
| Dihydroberberine |
