Introduction：Basic information about CAS 76472-87-2|Kuwanon H, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Kuwanon H |
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| CAS Number | 76472-87-2 | Molecular Weight | 760.82400 |
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| Density | 1.371g/cm3 | Boiling Point | 969.8ºC at 760 mmHg |
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| Molecular Formula | C45H44O11 | Melting Point | / |
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| MSDS | / | Flash Point | 292.5ºC |
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Names
| Name | kuwanone H |
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| Synonym | More Synonyms |
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Kuwanon H BiologicalActivity
| Description | Kuwanon H is a flavonoid isolated from Morus bombycis, which acts as a potent non-peptide bombesin receptor antagonist. Kuwanon H selectively inhibits binding of gastrin releasing peptide CRP to GRP-preferring recepotr, with a Ki value of 290 nM in cells[1]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>GPCR/G Protein >>Bombesin Receptor |
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| Target | Ki: 290 nM (GRP-preferring recepotr)[1] |
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| References | [1]. Mihara S, et al. Non-peptide bombesin receptor antagonists, kuwanon G and H, isolated from mulberry. Biochem Biophys Res Commun. 1995 Aug 15;213(2):594-9. |
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Chemical & Physical Properties
| Density | 1.371g/cm3 |
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| Boiling Point | 969.8ºC at 760 mmHg |
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| Molecular Formula | C45H44O11 |
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| Molecular Weight | 760.82400 |
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| Flash Point | 292.5ºC |
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| Exact Mass | 760.28800 |
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| PSA | 209.12000 |
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| LogP | 8.83870 |
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| Index of Refraction | 1.681 |
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| InChIKey | DKBPTKFKCCNXNH-QXGWMLRCSA-N |
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| SMILES | CC(C)=CCc1c(O)ccc(C(=O)C2C(c3c(O)cc(O)c4c(=O)c(CC=C(C)C)c(-c5ccc(O)cc5O)oc34)C=C(C)CC2c2ccc(O)cc2O)c1O |
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| Water Solubility | Insuluble (3.5E-6 g/L) (25 ºC) |
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Synonyms
| Albanin G |
| Alvanin G |
| kuwanon H |
| Moracenin A |
| NSC 356889 |
