CAS 4199-10-4|(S)-(-)-PROPRANOLOL HYDROCHLORIDE
| Common Name | (S)-(-)-PROPRANOLOL HYDROCHLORIDE | ||
|---|---|---|---|
| CAS Number | 4199-10-4 | Molecular Weight | 295.80400 |
| Density | / | Boiling Point | 434.9ºC at 760mmHg |
| Molecular Formula | C16H22ClNO2 | Melting Point | 193-195ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 216.8ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (s)-(-)-propranolol hydrochloride |
|---|---|
| Synonym | More Synonyms |
(S)-(-)-PROPRANOLOL HYDROCHLORIDE BiologicalActivity
| Description | (S)-(-)-Propranolol hydrochloride is a β-adrenergic receptor antagonist with log Kd values of -8.16, -9.08, and -6.93 for β1, β2, and β3, respectively. (S)-(-)-Propranolol hydrochloride the active enantiomer of propranolol and can be s used for study of hypertension, pheochromocytoma, myocardial infarction, cardiac arrhythmias, angina pectoris, and hypertrophic cardiomyopathy[2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorResearch Areas >>Inflammation/Immunology |
| Target | log Kd: -8.16 (β1-adrenergic receptor) log Kd: -9.08 (β2-adrenergic receptor) log Kd: -6.93 (β3-adrenergic receptor)[1] |
| References | [1]. Jillian G Baker , et al. The selectivity of beta-adrenoceptor antagonists at the human beta1, beta2 and beta3 adrenoceptors. Br J Pharmacol. 2005 Feb;144(3):317-22. |
Chemical & Physical Properties
| Boiling Point | 434.9ºC at 760mmHg |
|---|---|
| Melting Point | 193-195ºC(lit.) |
| Molecular Formula | C16H22ClNO2 |
| Molecular Weight | 295.80400 |
| Flash Point | 216.8ºC |
| Exact Mass | 295.13400 |
| PSA | 41.49000 |
| LogP | 3.77040 |
| Appearance of Characters | powder |
| InChIKey | ZMRUPTIKESYGQW-UQKRIMTDSA-N |
| SMILES | CC(C)NCC(O)COc1cccc2ccccc12.Cl |
| Storage condition | 2-8°C |
| Water Solubility | ethanol: 10 mg/mL |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H312-H332 |
| Precautionary Statements | P280 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | R20/21/22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2906199090 |
Customs
| HS Code | 2922509090 |
|---|---|
| Summary | 2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| dl-propranololHClbp |
| PROPRANOLOL HCL |
| dl-propranolol hcl |
| dl-propranololhydrochloridebp |
| PENTAPROPANOLOLHYDROCHLORIDE |
| Sazetidine A dihydrochloride |
| DL-PROPRANOLOL HYDROCHLORIDE |
| EINECS 224-096-0 |
| PROPANOLOL HYDROCHLORIDE |
| L-Propranololhydrochlorid |
| MFCD00064547 |
