Introduction：Basic information about CAS 4896-77-9|Glycine-d5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Glycine-d5 is the deuterium labeled Glycine. Glycine is an inhibitory neurotransmitter in the CNS and also acts as a co-agonist along with glutamate, facilitating an excitatory potential at the glutaminergic N-methyl-D-aspartic acid (NMDA) receptors.
Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].
References
[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216.
Chemical & Physical Properties
Density
1.3±0.1 g/cm3
Boiling Point
240.9±23.0 °C at 760 mmHg
Melting Point
240ºC (dec.)(lit.)
Molecular Formula
C2D5NO2
Molecular Weight
80.097
Flash Point
99.5±22.6 °C
Exact Mass
80.063416
PSA
63.32000
LogP
-1.03
Vapour Pressure
0.0±1.0 mmHg at 25°C
Index of Refraction
1.461
InChIKey
DHMQDGOQFOQNFH-LGLHGEJLSA-N
SMILES
NCC(=O)O
Storage condition
2-8°C
Safety Information
Safety Phrases
S24/25
RIDADR
NONH for all modes of transport
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