Introduction：Basic information about CAS 177931-17-8|Sauchinone, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Sauchinone |
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| CAS Number | 177931-17-8 | Molecular Weight | 356.369 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 498.1±45.0 °C at 760 mmHg |
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| Molecular Formula | C20H20O6 | Melting Point | 224-226℃ |
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| MSDS | ChineseUSA | Flash Point | 220.3±28.8 °C |
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Names
| Name | (5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro- 5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one |
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| Synonym | More Synonyms |
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Sauchinone BiologicalActivity
| Description | Sauchinone is a diastereomeric lignan isolated from Saururus chinensis (Saururaceae). Sauchinone inhibits LPS-inducible iNOS, TNF-α and COX-2 expression through suppression of I-κBα phosphorylation and p65 nuclear translocation. Sauchinone has anti-inflammatory and antioxidant activity[1]. |
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| Related Catalog | Research Areas >>Inflammation/Immunology |
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| Target | p65 I-kappaBalpha |
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| In Vitro | Sauchinone (1, 3, 10, 30μm; 6 hours) inhibits LPS-inducible increase in the iNOS mRNA in Raw264.7 cells[1]. Sauchinone at the concentrations of 3 and 30 μm inhibits TNF-α production in LPS-treated cells by 40 and 50%, respectively[1]. |
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| References | [1]. Lee AK, et al. Inhibition of lipopolysaccharide-inducible nitric oxide synthase, TNF-alpha and COX-2expression by sauchinone effects on I-kappaBalpha phosphorylation, C/EBP and AP-1 activation. Br J Pharmacol. 2003 May;139(1):11-20. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 498.1±45.0 °C at 760 mmHg |
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| Melting Point | 224-226℃ |
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| Molecular Formula | C20H20O6 |
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| Molecular Weight | 356.369 |
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| Flash Point | 220.3±28.8 °C |
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| Exact Mass | 356.125977 |
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| PSA | 63.22000 |
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| LogP | 3.81 |
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| Appearance of Characters | white to beige |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.643 |
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| InChIKey | GMTJIWUFFXGFHH-WPAOEJHSSA-N |
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| SMILES | CC1CC2C(=O)C=C3OCOC34Oc3cc5c(cc3C(C1C)C24)OCO5 |
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| Storage condition | 2-8°C |
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| Water Solubility | DMSO: soluble5mg/mL, clear (warmed) |
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Safety Information
| Safety Phrases | 24/25 |
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| RIDADR | NONH for all modes of transport |
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| HS Code | 29329990 |
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Synonyms
| (5aR,7R,8S,8aR,14aS,14bR)-7,8-Dimethyl-5a,6,7,8,8a,14b-hexahydro-5H-benzo[kl]bis[1,3]dioxolo[4,5-b:4',5'-g]xanthen-5-one |
| Sauchinone |
| 5H-Benzo[kl][1,3]dioxolo[4,5-b]-1,3-dioxolo[4,5-g]xanthen-5-one, 5a,6,7,8,8a,14b-hexahydro-7,8-dimethyl-, (5aR,7R,8S,8aR,14aS,14bR)- |
