Introduction：Basic information about CAS 212779-48-1|NG 52, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | NG 52 |
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| CAS Number | 212779-48-1 | Molecular Weight | 346.815 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 587.7±60.0 °C at 760 mmHg |
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| Molecular Formula | C16H19ClN6O | Melting Point | / |
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| MSDS | / | Flash Point | 309.2±32.9 °C |
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Names
| Name | 2-[[6-(3-chloroanilino)-9-propan-2-ylpurin-2-yl]amino]ethanol |
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| Synonym | More Synonyms |
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NG 52 BiologicalActivity
| Description | NG 52 (Compound 52 ) is a potent, cell-permeable, reversible, selective, and ATP-compatible inhibitor of the cell cycle-regulating kinase, Cdc28p (IC50 = 7 μM), and the related Pho85p kinase (IC50 = 2 μM).IC50 value: 7 uM [1]Target: Cdc28pCompound 52 inhibited growth in a drug-sensitized yeast strainwith a GI 50 of 30 uM. In contrast, the closely related compound 52Me proved to be a significantly weaker inhibitor of yeast growth (GI50=200 uM). |
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| Related Catalog | Research Areas >>Cancer |
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| Target | cdc2-cyclin B:0.34 μM (IC50) Pho85p:2 nM (IC50) |
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| References | [1]. ray NS, Wodicka L, Thunnissen AM et al. Exploiting chemical libraries, structure, and genomics in the search for kinase inhibitors. Science. 1998 Jul 24;281(5376):533-8. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 587.7±60.0 °C at 760 mmHg |
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| Molecular Formula | C16H19ClN6O |
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| Molecular Weight | 346.815 |
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| Flash Point | 309.2±32.9 °C |
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| Exact Mass | 346.130890 |
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| PSA | 91.12000 |
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| LogP | 1.54 |
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| Appearance of Characters | white solid |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.688 |
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| InChIKey | XZEFMZCNXDQXOZ-UHFFFAOYSA-N |
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| SMILES | CC(C)n1cnc2c(Nc3cccc(Cl)c3)nc(NCCO)nc21 |
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| Storage condition | -20℃ |
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Synonyms
| Ethanol, 2-[[6-[(3-chlorophenyl)amino]-9-(1-methylethyl)-9H-purin-2-yl]amino]- |
| 2-(2-Hydroxyethylamino)-6-(3-chloroanilino)-9-isopropylpurine NG-52 |
| OLP |
| 2-(2-HYDROXYETHYLAMINO)-6-(3-CHLOROANILINO)-9-ISOPROPYLPURINE |
| compound 52 |
| 2-({6-[(3-Chlorophenyl)amino]-9-isopropyl-9H-purin-2-yl}amino)ethanol |
| 3bpr |
| 2-({6-[(3-chlorophenyl)amino]-9-(propan-2-yl)-9H-purin-2-yl}amino)ethanol |
| NG-52 |
| NG 52 |
