CAS 94724-12-6|Compound 48/80

Introduction：Basic information about CAS 94724-12-6|Compound 48/80, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Compound 48/80 BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	Compound 48/80
CAS Number	94724-12-6	Molecular Weight	519.72
Density	/	Boiling Point	/
Molecular Formula	C₃₂H₄₅N₃O₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	hydrogen, 2-[4-methoxy-3-[[2-methoxy-3-[[2-methoxy-5-[2-(methylam ino)ethyl]phenyl]methyl]-5-[2-(methylamino)ethyl]phenyl]methyl]ph enyl]-N-methyl-ethanamine, dihydrochloride
Synonym	More Synonyms

Compound 48/80 BiologicalActivity

Description	Compound 48/80 (Poly-p-methoxyphenethylmethylamine) is widely used in animal and tissue models as a "selective" mast cell activator. Compound 48/80 acts at the mast cell membrane to stimulate trimeric G-proteins and induces degranulation via phospholipase C and D pathways[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease
Target	Mast Cell Activator[1]
In Vitro	Compound 48/80 (poly-p-methoxyphenethylmethylamine), an agent commonly used to trigger degranulation of mast cells, at concentrations of 5-20 μg/ml suppresses the proliferation of L1210 and Friend leukemic cells in vitro, inducing the formation of giant cells, which are polykaryons[3].
References	[1]. Schemann M, et al. The mast cell degranulator compound 48/80 directly activates neurons. PLoS One. 2012;7(12):e52104. [2]. Wang YH, Taché Y, Harris AG, Kreutner W, Daly AF, Wei JY. Desloratadine prevents compound 48/80-induced mast cell degranulation: visualization using a vital fluorescent dye technique. Allergy. 2005;60(1):117-124. [3]. Darzynkiewicz Z, Carter S. Compound 48/80 impairs cytokinesis in murine leukemic cells. J Cell Physiol. 1984;119(1):1-6.

Chemical & Physical Properties

Molecular Formula	C₃₂H₄₅N₃O₃
Molecular Weight	519.72
Exact Mass	597.34600
PSA	63.78000
LogP	6.95640
InChIKey	VLMSXEWVLQQTPJ-UHFFFAOYSA-N
SMILES	CNCCc1ccc(OC)c(Cc2cc(CCNC)cc(Cc3cc(CCNC)ccc3OC)c2OC)c1.Cl.Cl

Safety Information

Hazard Codes	T: Toxic;
Risk Phrases	23/24/25
Safety Phrases	22-24/25-45-36/37
RIDADR	UN 2811 6.1/PG 2

Synonyms

Benzenediazonium,2-carboxy-,chloride

MFCD00077679

compound 48/80

benzenediazonium 2-carboxylate hydrochloride

2-Carboxy-benzoldiazonium,Chlorid

o-carboxybenzenediazonium chloride

2-carboxy-benzenediazonium chloride

benzeneethanamine-4-methoxy-3,5-bis{(2-methoxy-5-(2-methylaminoethyl)phenyl)methyl-N-methyl}

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