Introduction：Basic information about CAS 941685-37-6|S-Ruxolitinib, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | S-Ruxolitinib |
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| CAS Number | 941685-37-6 | Molecular Weight | 306.365 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 592.6±50.0 °C at 760 mmHg |
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| Molecular Formula | C17H18N6 | Melting Point | / |
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| MSDS | / | Flash Point | 312.2±30.1 °C |
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Names
| Name | S-Ruxolitinib |
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| Synonym | More Synonyms |
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S-Ruxolitinib BiologicalActivity
| Description | Ruxolitinib S enantiomer is the S-enantiomer of Ruxolitinib. Ruxolitinib is the first potent, selective JAK1/2 inhibitor to enter the clinic with IC50 of 3.3 nM/2.8 nM in cell-free assays. |
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| Related Catalog | Signaling Pathways >>Autophagy >>AutophagyResearch Areas >>Cancer |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 592.6±50.0 °C at 760 mmHg |
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| Molecular Formula | C17H18N6 |
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| Molecular Weight | 306.365 |
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| Flash Point | 312.2±30.1 °C |
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| Exact Mass | 306.159302 |
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| PSA | 83.18000 |
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| LogP | 1.69 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.747 |
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| InChIKey | HFNKQEVNSGCOJV-HNNXBMFYSA-N |
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| SMILES | N#CCC(C1CCCC1)n1cc(-c2ncnc3[nH]ccc23)cn1 |
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| Storage condition | -20℃ |
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Synonyms
| 1H-Pyrazole-1-propanenitrile, β-cyclopentyl-4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-, (βS)- |
| ent-Ruxolitinib |
| (3S)-3-cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)pyrazol-1-yl]propanenitrile |
| Ruxolitinib (S enantiomer) |
| (3S)-3-Cyclopentyl-3-[4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl]propanenitrile |
| (S)-3-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1H-pyrazol-1-yl)-3-cyclopentylpropanenitrile |
| INCB018424 |
