CAS 74252-25-8|Indomethacin sodium hydrate
Introduction：Basic information about CAS 74252-25-8|Indomethacin sodium hydrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Indomethacin sodium hydrate | ||
|---|---|---|---|
| CAS Number | 74252-25-8 | Molecular Weight | 357.788 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 499.4±45.0 °C at 760 mmHg |
| Molecular Formula | C19H21ClNNaO7 | Melting Point | 162ºC |
| MSDS | / | Flash Point | 255.8±28.7 °C |
Names
| Name | sodium,2-[1-(4-chlorobenzoyl)-5-methoxy-2-methylindol-3-yl]acetate,trihydrate |
|---|---|
| Synonym | More Synonyms |
Indomethacin sodium hydrate BiologicalActivity
| Description | Indomethacin sodium hydrate (Indometacin sodium hydrate) is a potent, blood-brain permeable and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells[1]. Indomethacin sodium hydrate disrupts autophagic flux by disturbing the normal functioning of lysosomes[2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Autophagy >>AutophagyResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COX |
| In Vitro | Indomethacin is a potent and nonselective inhibitor of COX1 and COX2, with IC50s of 18 nM and 26 nM for human COX-1 and COX-2, respectively, in CHO cells. Indomethacin inhibits lipopolysaccharide (LPS)-induced PGE2 production (COX-2) in a human whole blood assay with a potency (IC50=0.68±0.17 μM), and suppresses coagulation-induced TXB2 production (COX-1) (IC50=0.19±0.02 μM). Indomethacin blocks COX-1 with an IC50 of 20±1 nM in U937 cell microsomes at a low arachidonic acid concentration (0.1 μM)[1]. |
| In Vivo | Indomethacin dose-dependently inhibits both the carrageenan-induced rat paw oedema (ED50, 2.0 mg/kg), hyperalgesia (ED50, 1.5 mg/kg), and is also effective at reversing LPS-induced pyrexia in rats (ED50, 1.1 mg/kg)[1]. Indomethacin (2.5 mg/kg, i.p) decreases the number of NeuN+ cells in the animals at 8 days after ET-1 injection. Indomethacin also reduces microglia/macrophage activation at 14 days. Indomethacin significantly increases the number of SVZ DCX+ cells/field at 14 days post stroke[3]. Indomethacin (22.9 mg/kg, p.o.) produces 8 to 10 linear mucosal lesions extended from the fundic to pyloric area of stomach wall[4]. |
| References | [1]. Riendeau D, et al. Biochemical and pharmacological profile of a tetrasubstituted furanone as a highly selective COX-2 inhibitor. Br J Pharmacol. 1997 May;121(1):105-17. [2]. Jorge Vallecillo-Hernández, et al. Indomethacin Disrupts Autophagic Flux by Inducing Lysosomal Dysfunction in Gastric Cancer Cells and Increases Their Sensitivity to Cytotoxic Drugs. Sci Rep. 2018 Feb 26;8(1):3593. [3]. Lopes RS, et al. Indomethacin treatment reduces microglia activation and increases numbers of neuroblasts in the subventricular zone and ischaemic striatum after focal ischaemia. J Biosci. 2016 Sep;41(3):381-94. [4]. Afroz S, et al. Concentrated phosphatidic acid in cereal brans as potential protective agents against indomethacin-induced stomach ulcer. J Agric Food Chem. 2016 Aug 26. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 499.4±45.0 °C at 760 mmHg |
| Melting Point | 162ºC |
| Molecular Formula | C19H21ClNNaO7 |
| Molecular Weight | 357.788 |
| Flash Point | 255.8±28.7 °C |
| Exact Mass | 357.076782 |
| PSA | 99.05000 |
| LogP | 3.11 |
| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
| Index of Refraction | 1.619 |
| InChIKey | UHYAQBLOGVNWNT-UHFFFAOYSA-M |
| SMILES | COc1ccc2c(c1)c(CC(=O)[O-])c(C)n2C(=O)c1ccc(Cl)cc1.O.O.O.[Na+] |
| Storage condition | -20℃ |
Synonyms
| Catlep |
| Indomethacinum |
| 1H-Indole-3-acetic acid, 1-(4-chlorobenzoyl)-5-methoxy-2-methyl- |
| Indomethacin sodium (USP) |
| 1H-Indole-3-acetic acid,1-(4-chlorobenzoyl)-5-methoxy-2-methyl-,sodium salt,trihydrate |
| Indomethacine |
| {1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl-1H-indol-3-yl}acetic acid |
| Durametacin |
| UNII-0IMX38M2GG |
| [1-(4-Chlorobenzoyl)-5-methoxy-2-methyl-1H-indol-3-yl]acetic acid |
| Dolcidium |
| Indomethacin sodium trihydrate |
| Chrono-indocid |
| Sodium 1-(p-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetate,trihydrate |
| Indometacin sodium (JAN) |
| indometacin |
| Na salt,tri-H2O |
| Indomethacin |
| Indocin I.V. (TN) |
| Chibro-amuno |
| Bonidon |
