CAS 74298-63-8|Chlormidazole hydrochloride

Introduction：Basic information about CAS 74298-63-8|Chlormidazole hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Chlormidazole hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Chlormidazole hydrochloride
CAS Number	74298-63-8	Molecular Weight	293.19100
Density	/	Boiling Point	467.5ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄Cl₂N₂	Melting Point	/
MSDS	/	Flash Point	236.5ºC

Names

Name	3-(4-Chlorobenzyl)-2-methyl-1H-benzimidazol-3-ium chloride
Synonym	More Synonyms

Chlormidazole hydrochloride BiologicalActivity

Description	Chlormidazole hydrochloride is an antifungal agent and has inhibitory activity against many fungi and some gram-positive cocci. Chlormidazole hydrochloride can be applied in fungal and bacterial infections of nails and skin, including interdigital and periungual mycoses[1].
Related Catalog	Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Fungal
Target	IC50: fungal[1]
References	[1]. Daniel J. Sheehan, et al. Current and Emerging Azole Antifungal Agents. Clin Microbiol Rev. 1999 Jan; 12(1): 40–79.

Chemical & Physical Properties

Boiling Point	467.5ºC at 760 mmHg
Molecular Formula	C₁₅H₁₄Cl₂N₂
Molecular Weight	293.19100
Flash Point	236.5ºC
Exact Mass	292.05300
PSA	17.82000
LogP	4.84840
InChIKey	MHMTXDMLQZHXRZ-UHFFFAOYSA-N
SMILES	Cc1nc2ccccc2n1Cc1ccc(Cl)cc1.Cl
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DD6700000

CHEMICAL NAME :: Benzimidazole, 1-(p-chlorobenzyl)-2-methyl-, hydrochloride

CAS REGISTRY NUMBER :: 74298-63-8

LAST UPDATED :: 199112

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C15-H13-Cl-N2.Cl-H

MOLECULAR WEIGHT :: 293.21

WISWESSER LINE NOTATION :: T56 BN DNJ B1R DG& C1 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 2200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 58 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >2 gm/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 90 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 250 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 9,489,1959

Safety Information

Hazard Codes	Xi

Synonyms

chloromethyl-trimethyl stannane

Trimethyl-chlormethyl-stannan

Chlorimidazole hydrochloride

Chlormethyl-trimethyl-zinn

Chlormethyl-trimethyl-stannan

chlormidazole hydrochloride

chloromethyl-trimethyl tin

Chlormethylen-trimethylzinn

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