CAS 122168-40-5|Gymnemic acid I

Introduction：Basic information about CAS 122168-40-5|Gymnemic acid I, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Gymnemic acid I BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	Gymnemic acid I
CAS Number	122168-40-5	Molecular Weight	806.976
Density	1.3±0.1 g/cm3	Boiling Point	872.1±65.0 °C at 760 mmHg
Molecular Formula	C₄₃H₆₆O₁₄	Melting Point	/
MSDS	/	Flash Point	252.8±27.8 °C

Names

Name	(2S,3S,4S,5R,6R)-6-[[(3S,4R,4aR,6aR,6bS,8S,8aR,9R,10R,12aS,14aR,14bR)-8a-(acetyloxymethyl)-8,9-dihydroxy-4-(hydroxymethyl)-4,6a,6b,11,11,14b-hexamethyl-10-[(E)-2-methylbut-2-enoyl]oxy-1,2,3,4a,5,6,7,8,9,10,12,12a,14,14a-tetradecahydropicen-3-yl]oxy]-3,4,5
Synonym	More Synonyms

Gymnemic acid I BiologicalActivity

Description	Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I decreases the apoptosis under the high glucose stress[1][2].
Related Catalog	Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease
References	[1]. Capolupo A, et al. Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics. J Nat Prod. 2017 Apr 28;80(4):909-915. [2]. Wu Y, et al. Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress. J Cell Physiol. 2019 Jun;234(6):9370-9377.

Description

Gymnemic acid I is a bioactive triterpene saponin found in Gymnema sylvestre. Gymnemic acid I decreases the apoptosis under the high glucose stress[1][2].

Related Catalog

Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease

References

[1]. Capolupo A, et al. Determination of Gymnemic Acid I as a Protein Biosynthesis Inhibitor Using Chemical Proteomics. J Nat Prod. 2017 Apr 28;80(4):909-915.

[2]. Wu Y, et al. Gymnemic acid I triggers mechanistic target of rapamycin-mediated β cells cytoprotection through the promotion of autophagy under high glucose stress. J Cell Physiol. 2019 Jun;234(6):9370-9377.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	872.1±65.0 °C at 760 mmHg
Molecular Formula	C₄₃H₆₆O₁₄
Molecular Weight	806.976
Flash Point	252.8±27.8 °C
Exact Mass	806.445251
PSA	229.74000
LogP	4.74
Vapour Pressure	0.0±0.6 mmHg at 25°C
Index of Refraction	1.596
InChIKey	VEFSVJGWJQPWFS-ZXKKMYOJSA-N
SMILES	CC=C(C)C(=O)OC1C(O)C2(COC(C)=O)C(O)CC3(C)C(=CCC4C5(C)CCC(OC6OC(C(=O)O)C(O)C(O)C6O)C(C)(CO)C5CCC43C)C2CC1(C)C

Synonyms

(3β,16β,21β,22α)-28-Acetoxy-16,22,23-trihydroxy-21-{[(2E)-2-methylbut-2-enoyl]oxy}olean-12-en-3-yl β-D-glucopyranosiduronic acid

gymnemic acid I

2-Butenoic acid, 2-methyl-, (3β,16β,21β,22α)-28-(acetyloxy)-3-(β-D-glucopyranuronosyloxy)-16,22,23-trihydroxyolean-12-en-21-yl ester, (2E)-

(3β,16β,21β,22α)-28-Acetoxy-16,22,23-trihydroxy-21-{[(2E)-2-methyl-2-butenoyl]oxy}olean-12-en-3-yl β-D-glucopyranosiduronic acid

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