CAS 88-32-4|TBMP
| Common Name | TBMP | ||
|---|---|---|---|
| CAS Number | 88-32-4 | Molecular Weight | 180.24 |
| Density | 1.009 g/cm3 | Boiling Point | 293.3ºC at 760 mmHg |
| Molecular Formula | C11H16O2 | Melting Point | 64℃ |
| MSDS | / | Flash Point | 136ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-tert-butyl-4-hydroxyanisole |
|---|---|
| Synonym | More Synonyms |
TBMP BiologicalActivity
| Description | 3-tert-Butyl-4-methoxyphenol is a PROTAC linker, belongs to alkyl/ether class, with insecticidal activity. 3-tert-Butyl-4-methoxyphenol also induced increased activities of glutathione (GSH) S-transferase and epoxide hydrolase in the liver and forestomach tissues of A/HeJ mice, regulating the carcinogen metabolism system[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>PROTAC >>PROTAC Linker |
| References | [1]. Lam LK, et al. Effects of 2- and 3-tert-butyl-4-hydroxyanisole on glutathione S-transferase and epoxide hydrolase activities and sulfhydryl levels in liver and forestomach of mice. Cancer Res. 1981 Oct;41(10):3940-3. [2]. Insecticide for vermin of order coleoptera. Japan, JP55136202 A 1980-10-23. |
Chemical & Physical Properties
| Density | 1.009 g/cm3 |
|---|---|
| Boiling Point | 293.3ºC at 760 mmHg |
| Melting Point | 64℃ |
| Molecular Formula | C11H16O2 |
| Molecular Weight | 180.24 |
| Flash Point | 136ºC |
| Exact Mass | 180.11500 |
| PSA | 29.46000 |
| LogP | 2.69830 |
| Index of Refraction | 1.507 |
| InChIKey | IMOYOUMVYICGCA-UHFFFAOYSA-N |
| SMILES | COc1ccc(O)cc1C(C)(C)C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - hamster
- DOSE/DURATION :
- 27 gm/kg/3W-C
- TOXIC EFFECTS :
- Tumorigenic - equivocal tumorigenic agent by RTECS criteria Gastrointestinal - tumors
- REFERENCE :
- JJIND8 JNCI, Journal of the National Cancer Institute. (Washington, DC) V.61-79, 1978-87. For publisher information, see JNCIEQ. Volume(issue)/page/year: 76,143,1986
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Hazard Codes | Xn |
| Risk Phrases | 22-36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933990090 |
Customs
| HS Code | 2909500000 |
|---|---|
| Summary | 2909500000 ether-phenols, ether-alcohol-phenols and their halogenated, sulphonated, nitrated or nitrosated derivatives VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
Articles14
More Articles| Modulation by dietary factors of BHA-induced alterations in cell kinetics of gastro-intestinal tract tissues in rats. Food Chem. Toxicol. 29(2) , 79-85, (1991) To determine the effects of dietary ethanol or fibre on 2(3)-tert-butyl-4-hydroxyanisole (BHA)-induced alterations in cell kinetics in gastro-intestinal tract tissues, groups of six male Wistar rats w... | |
| Antioxidant properties of melatonin: a pulse radiolysis study. Free Radic. Biol. Med. 26(5-6) , 557-65, (1999) Various one-electron oxidants such as OH*, tert-BuO*, CCl3OO*, Br2*- and N3*, generated pulse radiolytically in aqueous solutions at pH 7, were scavenged by melatonin to form two main absorption bands... | |
| Chemoprevention of cancer: phenolic antioxidants (BHT, BHA). Int. J. Biochem. 20(7) , 639-51, (1988) 1. The synthetic phenolic antioxidants (e.g. BHT, BHA) added to human and animal food are able to lengthen the life of organisms and lower the incidence of cancer caused by chemical compounds. 2. On t... |
Synonyms
| 2-TERT-BUTYL-4-HYDROXYANISOLE |
| 4-Methoxy-3-te |
| 2-BHA |
| 3-tert-Bha |
| 2-TERT-BUTYLHYDROXYANISOLE |
| 3-tert-butyl-4-methoxy-pheno |
| 2-T-BUTYL-4-HYDROXYANISOLE |
| 3-TERT-BUTYL-4-METHOXYPHENOL |
| 4-Methoxy-3 |
