CAS 22140-20-1|2-Methylthio-AMP TEA salt
Introduction：Basic information about CAS 22140-20-1|2-Methylthio-AMP TEA salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Methylthio-AMP TEA salt | ||
|---|---|---|---|
| CAS Number | 22140-20-1 | Molecular Weight | 393.31300 |
| Density | / | Boiling Point | / |
| Molecular Formula | C11H16N5O7PS | Melting Point | / |
| MSDS | USA | Flash Point | / |
Names
| Name | 2-methylthioadenosine 5-monophosphate |
|---|---|
| Synonym | More Synonyms |
2-Methylthio-AMP TEA salt BiologicalActivity
| Description | 2-Methylthio-AMP (2-MeSAMP) is a selective and direct P2Y12 antagonist. 2-Methylthio-AMP is an inhibitor of ADP-dependent platelet aggregation[1][2][3]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>P2Y Receptor |
| Target | P2Y12[1] |
| In Vitro | 2-Methylthio-AMP (2-MeSAMP) inhibits agonist-mediated αIIbβ3 activation in platelets[1]. 2-methylthio-AMP (50 μM; for 5 minutes) does not significantly inhibit thrombin, PAR1-AP, PAR4-AP, or ADP-mediated platelet Ca2+ mobilization. 2-methylthio-AMP fails to inhibit Ca2+ mobilization in P2Y12-deficient mouse platelets and does not raise cAMP or induce vasodilator-stimulated phosphoprotein phosphorylation in wild-type platelets[1]. |
| References | [1]. John H Cleator, et al. Racial differences in resistance to P2Y12 receptor antagonists in type 2 diabetic subjects. J Pharmacol Exp Ther. 2014 Oct;351(1):33-43. [2]. Bernhard H Rauch, et al. Regulation of functionally active P2Y12 ADP receptors by thrombin in human smooth muscle cells and the presence of P2Y12 in carotid artery lesions. Arterioscler Thromb Vasc Biol. 2010 Dec;30(12):2434-42. [3]. A Malinin, et al. Validation of a VerifyNow-P2Y12 cartridge for monitoring platelet inhibition with clopidogrel. Methods Find Exp Clin Pharmacol. 2006 Jun;28(5):315-22. |
Chemical & Physical Properties
| Molecular Formula | C11H16N5O7PS |
|---|---|
| Molecular Weight | 393.31300 |
| Exact Mass | 393.05100 |
| PSA | 221.18000 |
| InChIKey | KILPFOKXXXUFNN-IDIVVRGQSA-N |
| SMILES | CCN(CC)CC.CCN(CC)CC.CSc1nc(N)c2ncn(C3OC(COP(=O)(O)O)C(O)C3O)c2n1 |
Synonyms
| 2-methylthioadenosine 5'-monophosphate triethylammonium salt hydrate |
| 2-MeSAMP,2-Methylthio-AMP hydrate triethylammonium salt |
| 2-Methylthio-AMP |
| 2-mesamp |
| 2,6,2',6'-TETRAMETHYLAZOBENZENE NN'-DIOXIDE---CRYSTALLINE |
| 2-methylthioadenosine-5'-monophosphate |
