Introduction：Basic information about CAS 41498-37-7|GS-389, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | GS-389 |
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| CAS Number | 41498-37-7 | Molecular Weight | 313.39100 |
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| Density | 1.108g/cm3 | Boiling Point | 454ºC at 760 mmHg |
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| Molecular Formula | C19H23NO3 | Melting Point | / |
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| MSDS | / | Flash Point | 191.6ºC |
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Names
| Name | 6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]-1,2,3,4-tetrahydroisoquinoline |
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| Synonym | More Synonyms |
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GS-389 BiologicalActivity
| Description | GS 389 ((±)-O,O-Dimethylcoclaurine) is a tetrahydroisoquinoline. GS-389 inhibites Cyclic AMP and cyclic AMP dependent phosphodiesterases from rat atrial and ventricular tissue. GS-389 relaxes the contraction induced by phenylephrine and high K+ in rat aortic rings[1]. |
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| Related Catalog | Research Areas >>Metabolic Disease |
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| References | [1]. Chang KC, et al. Different pharmacological characteristics of structurally similar benzylisoquinoline analogs, papaverine, higenamine, and GS 389, on isolated rat aorta and heart. Can J Physiol Pharmacol. 1994;72(4):327-334. |
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Chemical & Physical Properties
| Density | 1.108g/cm3 |
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| Boiling Point | 454ºC at 760 mmHg |
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| Molecular Formula | C19H23NO3 |
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| Molecular Weight | 313.39100 |
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| Flash Point | 191.6ºC |
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| Exact Mass | 313.16800 |
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| PSA | 39.72000 |
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| LogP | 3.47070 |
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| Index of Refraction | 1.557 |
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| InChIKey | GXTUEUWFEKEQHJ-UHFFFAOYSA-N |
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| SMILES | COc1ccc(CC2NCCc3cc(OC)c(OC)cc32)cc1 |
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Safety Information
Customs
| HS Code | 2933499090 |
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| Summary | 2933499090. other compounds containing in the structure a quinoline or isoquinoline ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| coclaurine dimethyl ether |
| 1,2,3,4-tetrahydro-6,7-dimethoxy-1-[(4-methoxyphenyl)methyl]isoquinoline |
| 7,12-O,O'-dimethylcoclaurine |
| N-(3,4-dimethoxyphenylethyl)-2-(3-methoxyphenyl)acetamide |
| 6,7-dimethoxy-1-(4-methoxy-benzyl)-1,2,3,4-tetrahydroisoquinoline |
| rac-O,O-dimethylcoclaurine |
| GS-389 |
| (+/-)-1-(4-methoxybenzyl)-6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline |
