Introduction：Basic information about CAS 56066-63-8|Aditoprime, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aditoprime |
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| CAS Number | 56066-63-8 | Molecular Weight | 303.36000 |
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| Density | 1.233g/cm3 | Boiling Point | 503.9ºC at 760 mmHg |
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| Molecular Formula | C15H21N5O2 | Melting Point | / |
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| MSDS | / | Flash Point | 258.5ºC |
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Names
| Name | 5-[[4-(dimethylamino)-3,5-dimethoxyphenyl]methyl]pyrimidine-2,4-diamine |
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| Synonym | More Synonyms |
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Aditoprime BiologicalActivity
| Description | Aditoprime (Aditoprim), a selective bacterial dihydrofolate reductase (DHFR) inhibitor, inhibits the transformation of dihydrofolic acid to tetrahydrofolic acid. Aditoprime inhibits E.coli and L.casei DHFR with IC50 of 47 and 520 nM, respectively. Aditoprime has a broad antimicrobial spectrum, good antibacterial activity and excellent pharmacokinetics[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>AntifolateSignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Aditoprime has the same antibacterial spectrum as TMP. Salmonellaand Streptococcus from swine, E. coli and Salmonella from chickens, E. coli, Streptococcus, Mannheimia, and Pasteurella from calves, Streptococcus and Mannheimia from sheep, and E. coli, Flavobacterium columnare, A. baumannii and Y. ruckeri from fishes are highly susceptible to Aditoprime (MIC or MIC50 ≤ 4 μg/mL)[1]. |
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| In Vivo | Aditoprime (Aditoprim) has longer elimination half-lives (3.3~14.8 h) and higher distribution volumes (4.6~10.4 L/kg) than those of Trimethoprim (TMP) in pig, calf, monkey, sheep and some other animal species, and a similar pattern is observed for Aditoprime where the distribution volume is about four times higher than that of TMP[1]. Aditoprime (10 -40 mg/kg; b.w.; intramuscularly) shows efficacy in infected swine (swine streptococcosis)[1]. |
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| References | [1]. Then RL, et al. Properties of aditoprim, a new antibacterial dihydrofolate reductase inhibitor. Zentralbl Veterinarmed B. 1988;35(2):114-120. [2]. Cheng G, et al. The antibacterial activities of aditoprim and its efficacy in the treatment of swine streptococcosis. Sci Rep. 2017;7:41370. Published 2017 Feb 1. [3]. Wang X, et al. Two-generation reproduction and teratology studies of feeding aditoprim in Wistar rats. J Appl Toxicol. 2015;35(12):1531-1538. |
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Chemical & Physical Properties
| Density | 1.233g/cm3 |
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| Boiling Point | 503.9ºC at 760 mmHg |
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| Molecular Formula | C15H21N5O2 |
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| Molecular Weight | 303.36000 |
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| Flash Point | 258.5ºC |
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| Exact Mass | 303.17000 |
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| PSA | 100.98000 |
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| LogP | 1.17520 |
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| Index of Refraction | 1.633 |
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| InChIKey | QBQMXWZTRRWPGK-UHFFFAOYSA-N |
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| SMILES | COc1cc(Cc2cnc(N)nc2N)cc(OC)c1N(C)C |
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Safety Information
Synonyms
| Aditoprima |
| Aditoprim |
| Aditoprime |
