Introduction：Basic information about CAS 465-13-4|Neritaloside, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Neritaloside |
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| CAS Number | 465-13-4 | Molecular Weight | 592.718 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 729.4±60.0 °C at 760 mmHg |
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| Molecular Formula | C32H48O10 | Melting Point | / |
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| MSDS | / | Flash Point | 229.4±26.4 °C |
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Names
| Name | Neritaloside |
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| Synonym | More Synonyms |
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Neritaloside BiologicalActivity
| Description | Neritaloside could be isolated from nerium oleander. Neritaloside has central nervous system (CNS) depressant effect[1][2. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological Disease |
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| In Vitro | Neritaloside (human tumor cell lines) has antitumor activity with mean IC50 value and mean IC70 value of 0.120 μM and 0.252 μM, respectively[1]. |
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| In Vivo | Neritaloside (25 mg/kg; i.p.; for 6 hours; mice of NMRI strain) exhibits central nervous system depressant activity in mice at a dose of 25 mg/kg[2. Animal Model: Mice of NMRI strain (18-22 g) [2 Dosage: 25 mg/kg Administration: Intraperitoneal injection; for 6 hours Result: Showed sedation in mice at 25 mg/kg dose. |
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| References | [1]. Rashan LJ, et, al. Characterization of the anticancer properties of monoglycosidic cardenolides isolated from Nerium oleander and Streptocaulon tomentosum. J Ethnopharmacol. 2011 Apr 12;134(3):781-8. [2]. Begum S, et, al. Bio-active cardenolides from the leaves of Nerium oleander. Phytochemistry. 1999 Feb;50(3):435-8. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 729.4±60.0 °C at 760 mmHg |
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| Molecular Formula | C32H48O10 |
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| Molecular Weight | 592.718 |
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| Flash Point | 229.4±26.4 °C |
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| Exact Mass | 592.324768 |
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| PSA | 140.98000 |
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| LogP | 3.00 |
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| Vapour Pressure | 0.0±5.4 mmHg at 25°C |
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| Index of Refraction | 1.578 |
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| InChIKey | UZQOZJNEDXAJEZ-JWMMVCOUSA-N |
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| SMILES | COC1C(O)C(C)OC(OC2CCC3(C)C(CCC4C3CCC3(C)C(C5=CC(=O)OC5)C(OC(C)=O)CC43O)C2)C1O |
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Safety Information
Synonyms
| Card-20(22)-enolide, 16-(acetyloxy)-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxy-, (3β,5β,16β)- |
| (3β,5β,16β)-16-Acetoxy-3-[(6-deoxy-3-O-methyl-β-D-galactopyranosyl)oxy]-14-hydroxycard-20(22)-enolide |
