Introduction：Basic information about CAS 87686-86-0|6-Hydroxyrubiadin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 6-Hydroxyrubiadin |
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| CAS Number | 87686-86-0 | Molecular Weight | 270.237 |
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| Density | 1.6±0.1 g/cm3 | Boiling Point | 558.7±19.0 °C at 760 mmHg |
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| Molecular Formula | C15H10O5 | Melting Point | / |
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| MSDS | / | Flash Point | 305.7±18.0 °C |
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Names
| Name | 6-Hydroxyrubiadin |
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| Synonym | More Synonyms |
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6-Hydroxyrubiadin BiologicalActivity
| Description | 6-Hydroxyrubiadin, a natural anthraquinone, may be a potential therapeutic candidate for the treatment of inflammation and inflammatory diseases[1]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
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| In Vitro | 6-hydroxyrubiadin suppresses lipopolysaccharide (LPS)-induced nuclear factor-kappa B activation as well as the phosphorylation of c-Jun N-terminal kinase in RAW 264.7 macrophages[1]. 6-hydroxyrubiadin inhibited the expression of tumor necrosis factor (TNF)-a, interleukin (IL)-1b and IL-6 in phorbol myristate acetate (PMA)-primed U937 and RAW 264.7cells[1]. |
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| In Vivo | 6-hydroxyrubiadin can reduce the production of pro-inflammatory cytokines and ameliorate acute lung injury (ALI) in a mouse model[1]. |
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| References | [1]. Yanting Wu, et al. In vitro and in vivo inhibitory effects of 6-hydroxyrubiadin on lipopolysaccharide-induced inflammation. Immunopharmacol Immunotoxicol. 2017 Jun;39(3):107-116. |
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Chemical & Physical Properties
| Density | 1.6±0.1 g/cm3 |
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| Boiling Point | 558.7±19.0 °C at 760 mmHg |
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| Molecular Formula | C15H10O5 |
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| Molecular Weight | 270.237 |
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| Flash Point | 305.7±18.0 °C |
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| Exact Mass | 270.052826 |
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| PSA | 94.83000 |
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| LogP | 4.42 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.745 |
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| InChIKey | JKJVBHYKKRDSPP-UHFFFAOYSA-N |
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| SMILES | Cc1c(O)cc2c(c1O)C(=O)c1ccc(O)cc1C2=O |
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Safety Information
Synonyms
| 1,3,6-Trihydroxy-2-methyl-9,10-anthraquinone |
| 1,3,6-trihydroxy-2-methylanthracene-9,10-dione |
| 9,10-Anthracenedione, 1,3,6-trihydroxy-2-methyl- |
| 2-Methyl-1,3,6-trihydroxyanthraquinone |
