CAS 90902-21-9|Broussonin E
Introduction：Basic information about CAS 90902-21-9|Broussonin E, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Broussonin E | ||
|---|---|---|---|
| CAS Number | 90902-21-9 | Molecular Weight | 288.338 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 464.9±40.0 °C at 760 mmHg |
| Molecular Formula | C17H20O4 | Melting Point | / |
| MSDS | / | Flash Point | 235.0±27.3 °C |
Names
| Name | Broussonin E |
|---|---|
| Synonym | More Synonyms |
Broussonin E BiologicalActivity
| Description | Broussonin E is a phenolic compound and shows anti-inflammatory activity. Broussonin E can suppress inflammation by modulating macrophages activation statevia inhibiting the ERK and p38 MAPK and enhancing JAK2-STAT3 signaling pathway. Broussonin E can be used for the research of inflammation-related diseases such as atherosclerosis[1]. |
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| Related Catalog | Signaling Pathways >>Stem Cell/Wnt >>STATSignaling Pathways >>JAK/STAT Signaling >>JAKSignaling Pathways >>Epigenetics >>JAKSignaling Pathways >>Stem Cell/Wnt >>JAKSignaling Pathways >>JAK/STAT Signaling >>STATSignaling Pathways >>Immunology/Inflammation >>Interleukin RelatedSignaling Pathways >>MAPK/ERK Pathway >>p38 MAPKResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>COXSignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>Immunology/Inflammation >>ArginaseSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | ERK p38 MAPK JAK2 STAT3 IL-1β IL-6 COX-2 IL-10 |
| In Vitro | Broussonin E (20 μM, 3 h) 抑制 LPS (Lipopolysaccharides，HY-D1056) 刺激的磷酸化 ERK 和 p38 MAPK[1]。 Broussonin E 可激活 janus 激酶 (JAK) 2、信号转导和转录激活因子 (STAT) 3[1]。 Broussonin E (0-20 μM, 3 h) 可抑制 RAW264.7 细胞中 LPS 诱导的促炎产生，包括 TNF-α、IL-1β、IL-6、COX-2 和 iNOS[1 ]. Broussonin E 增强 LPS 刺激的 RAW264.7 细胞中抗炎介质如 IL-10、CD206 和精氨酸酶-1 (Arg-1) 的表达[1]。 Western Blot Analysis[1] Cell Line: RAW264.7 cells Concentration: 2.5, 5, 10 and 20 Incubation Time: 3 h Result: Inhibited p-ERK and p-p38 MAPK, but not p-JNK MAPK expression in LPS-stimulated RAW264.7 cells. |
| References | [1]. Huang SP, et al. Broussonin E suppresses LPS-induced inflammatory response in macrophages via inhibiting MAPK pathway and enhancing JAK2-STAT3 pathway. Chin J Nat Med. 2019 May 20;17(5):372-380. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 464.9±40.0 °C at 760 mmHg |
| Molecular Formula | C17H20O4 |
| Molecular Weight | 288.338 |
| Flash Point | 235.0±27.3 °C |
| Exact Mass | 288.136169 |
| PSA | 58.92000 |
| LogP | 3.35 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.586 |
| InChIKey | GDCSYNUJDYRGRF-UHFFFAOYSA-N |
| SMILES | COc1ccc(CCCc2ccc(OC)c(O)c2)c(O)c1 |
Safety Information
| Hazard Codes | Xi |
|---|
Synonyms
| Phenol, 5-[3-(2-hydroxy-4-methoxyphenyl)propyl]-2-methoxy- |
| 5-[3-(2-Hydroxy-4-methoxyphenyl)propyl]-2-methoxyphenol |
