CAS 87402-88-8|(-)-Denudatin B

Introduction：Basic information about CAS 87402-88-8|(-)-Denudatin B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (-)-Denudatin B BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(-)-Denudatin B
CAS Number	87402-88-8	Molecular Weight	356.41
Density	1.2±0.1 g/cm3	Boiling Point	491.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄O₅	Melting Point	/
MSDS	/	Flash Point	214.2±28.8 °C

Names

Name	Denudatin B
Synonym	More Synonyms

(-)-Denudatin B BiologicalActivity

Description	(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels[1]. And (-)-Denudatin B has nonspecific antiplatelet action
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease
References	[1]. Yu SM,et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187(1):39-47. [2]. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59(1):121-130.

Description

(-)-Denudatin B is an antiplatelet agent. (-)-Denudatin B relaxed vascular smooth muscle by inhibiting the Ca2+ influx through voltage-gated and receptor-operated Ca2+ channels[1]. And (-)-Denudatin B has nonspecific antiplatelet action

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Cardiovascular Disease

References

[1]. Yu SM,et al. Vasorelaxing effect in rat thoracic aorta caused by denudatin B, isolated from the Chinese herb, magnolia fargesii. Eur J Pharmacol. 1990;187(1):39-47.

[2]. Teng CM, et al. Inhibition of thrombin- and collagen-induced phosphoinositides breakdown in rabbit platelets by a PAF antagonist--denudatin B, an isomer of kadsurenone. Thromb Res. 1990;59(1):121-130.

Chemical & Physical Properties

Density	1.2±0.1 g/cm3
Boiling Point	491.1±45.0 °C at 760 mmHg
Molecular Formula	C₂₁H₂₄O₅
Molecular Weight	356.41
Flash Point	214.2±28.8 °C
Exact Mass	356.162384
PSA	53.99000
LogP	2.87
Vapour Pressure	0.0±1.2 mmHg at 25°C
Index of Refraction	1.565
InChIKey	VDYACOATPFOZIO-HBUDHLSFSA-N
SMILES	C=CCC1=CC2(OC)C(=CC1=O)OC(c1ccc(OC)c(OC)c1)C2C

Safety Information

Hazard Codes	Xi

Synonyms

(2S,3R,3aR)-5-Allyl-2-(3,4-dimethoxyphenyl)-3a-methoxy-3-methyl-3,3a-dihydro-1-benzofuran-6(2H)-one

Denudatin B

6(2H)-Benzofuranone, 2-(3,4-dimethoxyphenyl)-3,3a-dihydro-3a-methoxy-3-methyl-5-(2-propen-1-yl)-, (2S,3R,3aR)-

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