CAS 76-80-2|Tephrosin
| Common Name | Tephrosin | ||
|---|---|---|---|
| CAS Number | 76-80-2 | Molecular Weight | 410.417 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 623.4±55.0 °C at 760 mmHg |
| Molecular Formula | C23H22O7 | Melting Point | 198° (218-220°) |
| MSDS | USA | Flash Point | 219.3±25.0 °C |
| Symbol | GHS09 | Signal Word | Warning |
Names
| Name | tephrosin |
|---|---|
| Synonym | More Synonyms |
Tephrosin BiologicalActivity
| Description | Tephrosin is a natural rotenoid which has potent antitumor activities. Tephrosin induces degradation of of EGFR and ErbB2 by inducing internalization of the receptors[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerSignaling Pathways >>Others >>Others |
| In Vitro | Treatment of HT-29 cells with tephrosin (0-10μM) inhibits both the ligand-induced and constitutive phosphorylation of EGFR, ErbB2 and ErbB3, and concomitantly suppresses the activation of the downstream signaling molecules such as Akt and Erk1/2 mitogen-activated protein kinase (MAPK) [1]. |
| References | [1]. Choi S, et al. Tephrosin induces internalization and degradation of EGFR and ErbB2 in HT-29 human colon cancer cells. Cancer Lett. 2010 Jul 1;293(1):23-30. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 623.4±55.0 °C at 760 mmHg |
| Melting Point | 198° (218-220°) |
| Molecular Formula | C23H22O7 |
| Molecular Weight | 410.417 |
| Flash Point | 219.3±25.0 °C |
| Exact Mass | 410.136566 |
| PSA | 83.45000 |
| LogP | 4.48 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.614 |
| InChIKey | AQBZCCQCDWNNJQ-AUSIDOKSSA-N |
| SMILES | COc1cc2c(cc1OC)C1(O)C(=O)c3ccc4c(c3OC1CO2)C=CC(C)(C)O4 |
| Storage condition | ?20°C |
Safety Information
| Symbol | GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P501 |
| Hazard Codes | N |
| Risk Phrases | 50 |
| Safety Phrases | 61 |
| RIDADR | UN 3077 9 / PGIII |
| Hazard Class | 9.0 |
Articles14
More Articles| [Rotenoids from Derris trifoliata]. Zhong Yao Cai 30(6) , 660-2, (2007) Five rotenoids named dehydrodeguelin, dehydrorotenone, 12a-hydroxy rotenone, tephrosin and 12alphabeta-hydroxyrot-2'-enonic acid were isolated from aerial parts of Derris trifoliata. All these compoun... | |
| Preparative isolation and purification of three rotenoids and one isoflavone from the seeds of Millettia pachycarpa Benth by high-speed counter-current chromatography. J. Chromatogr. A. 1178(1-2) , 101-7, (2008) Both analytical and preparative high-speed counter-current chromatography (HSCCC) were used to isolate and separate chemical bioactive constituents from the seeds of Millettia pachycarpa Benth, a famo... | |
| Effect of rotenoids from the seeds of Millettia dura on larvae of Aedes aegypti. Pest Manag. Sci. 59(10) , 1159-61, (2003) A crude chloroform extract of seeds of Millettia dura Dunn (Leguminosae) showed high activity (LC50 = 3.5 microg ml(-1) at 24 h) against second-instar larvae of the mosquito, Aedes aegypti L (Diptera:... |
Synonyms
| Tephrosin |
| Toxicarol |
| (7aR,13aR)-7a-Hydroxy-9,10-dimethoxy-3,3-dimethyl-13,13a-dihydro-3H-chromeno[3,4-b]pyrano[2,3-h]chromen-7(7aH)-one |
| 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aR,13aR)- |
| 3H-Bis(1)benzopyrano(3,4-b:6',5'-e)pyran-7(7aH)-one, 13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aR-cis)- |
| Hydroxydeguelin |
| (7aR-cis)-13,13a-Dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-3H-bis[1]benzopyrano[3,4-b:6',5'-e]pyran-7(7aH)-one |
| 3H-[1]Benzopyrano[3,4-b]pyrano[2,3-h][1]benzopyran-7(7aH)-one, 13,13a-dihydro-7a-hydroxy-9,10-dimethoxy-3,3-dimethyl-, (7aR,13aR)- |
