CAS 23513-15-7|10-Gingerol

Introduction：Basic information about CAS 23513-15-7|10-Gingerol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 10-Gingerol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles3
8. Synonyms

Common Name	10-Gingerol
CAS Number	23513-15-7	Molecular Weight	350.492
Density	1.0±0.1 g/cm3	Boiling Point	499.7±35.0 °C at 760 mmHg
Molecular Formula	C₂₁H₃₄O₄	Melting Point	45 - 46 °C
MSDS	ChineseUSA	Flash Point	166.4±19.4 °C

Names

Name	[10]-Gingerol
Synonym	More Synonyms

10-Gingerol BiologicalActivity

Description	10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2].
Related Catalog	Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology
References	[1]. Dugasani S, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127(2):515-20. [2]. Almada da Silva J, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62.

Description

10-Gingerol is a major pungent constituent in the ginger oleoresin from fresh rhizome, with anti-inflammatory, antioxidant and anti-proliferative activities. 10-Gingerol inhibits the proliferation of MDA-MB-231 tumor cell line with an IC50 of 12.1 μM[1][2].

Related Catalog

Research Areas >>CancerSignaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology

References

[1]. Dugasani S, et al. Comparative antioxidant and anti-inflammatory effects of [6]-gingerol, [8]-gingerol, [10]-gingerol and [6]-shogaol. J Ethnopharmacol. 2010 Feb 3;127(2):515-20.

[2]. Almada da Silva J, et al. Purification and differential biological effects of ginger-derived substances on normal and tumor cell lines. J Chromatogr B Analyt Technol Biomed Life Sci. 2012 Aug 15;903:157-62.

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	499.7±35.0 °C at 760 mmHg
Melting Point	45 - 46 °C
Molecular Formula	C₂₁H₃₄O₄
Molecular Weight	350.492
Flash Point	166.4±19.4 °C
Exact Mass	350.245697
PSA	66.76000
LogP	4.61
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.513
InChIKey	AIULWNKTYPZYAN-SFHVURJKSA-N
SMILES	CCCCCCCCCC(O)CC(=O)CCc1ccc(O)c(OC)c1
Storage condition	2-8°C
Water Solubility	methanol: soluble5mg/mL, clear, colorless

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: XB8720000

CHEMICAL NAME :: 3-Tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-

CAS REGISTRY NUMBER :: 23513-15-7

LAST UPDATED :: 199503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C21-H34-O4

MOLECULAR WEIGHT :: 350.55

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 25,231,1990

Safety Information

Hazard Statements	H413
Hazard Codes	T+
Risk Phrases	53
Safety Phrases	24/25
RIDADR	NONH for all modes of transport
HS Code	2914509090

Customs

HS Code	2914509090
Summary	HS:2914509090 other ketones with other oxygen function VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0%

Articles3

Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.

J. Pharm. Pharmacol. 67(4) , 583-96, (2015)

To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and ...

Identification of serotonin 5-HT1A receptor partial agonists in ginger.

Bioorg. Med. Chem. 18 , 3345-51, (2010)

Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the hu...

Antiallergic potential on RBL-2H3 cells of some phenolic constituents of Zingiber officinale (ginger).

J. Nat. Prod. 72 , 950-3, (2009)

In the present study on five pure phenolic compounds (1-5) isolated from the rhizomes of Zingiber officinale (ginger) and investigated for their antiallergic potency, rat basophilic leukemia (RBL-2H3)...

Synonyms

(S)- 5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone

(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-tetradecanone

(5s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)tetradecan-3-one

<10>-Gingerol

10-Gingerol

3-Tetradecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-

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