CAS 2018-66-8|Z-Leu-OH
Introduction：Basic information about CAS 2018-66-8|Z-Leu-OH, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Z-Leu-OH | ||
|---|---|---|---|
| CAS Number | 2018-66-8 | Molecular Weight | 265.305 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 442.8±38.0 °C at 760 mmHg |
| Molecular Formula | C14H19NO4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 221.6±26.8 °C |
| Symbol | GHS02, GHS08 | Signal Word | Warning |
Names
| Name | N-benzyloxycarbonyl-L-leucine |
|---|---|
| Synonym | More Synonyms |
Z-Leu-OH BiologicalActivity
| Description | N-[(Phenylmethoxy)carbonyl]-L-leucine is a leucine derivative[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | Amino acids and amino acid derivatives have been commercially used as ergogenic supplements. They influence the secretion of anabolic hormones, supply of fuel during exercise, mental performance during stress related tasks and prevent exercise induced muscle damage. They are recognized to be beneficial as ergogenic dietary substances[1]. |
| References | [1]. Luckose F, et al. Effects of amino acid derivatives on physical, mental, and physiological activities. Crit Rev Food Sci Nutr. 2015;55(13):1793-1144. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 442.8±38.0 °C at 760 mmHg |
| Molecular Formula | C14H19NO4 |
| Molecular Weight | 265.305 |
| Flash Point | 221.6±26.8 °C |
| Exact Mass | 265.131409 |
| PSA | 75.63000 |
| LogP | 3.12 |
| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
| Index of Refraction | 1.528 |
| InChIKey | USPFMEKVPDBMCG-LBPRGKRZSA-N |
| SMILES | CC(C)CC(NC(=O)OCc1ccccc1)C(=O)O |
| Storage condition | 2~8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravaginal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >1 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979 ** REPRODUCTIVE DATA **
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intravaginal
- DOSE :
- 280 mg/kg
- SEX/DURATION :
- female 28 day(s) pre-mating
- TOXIC EFFECTS :
- Reproductive - Fertility - female fertility index (e.g. # females pregnant per # sperm positive females; # females pregnant per # females mated)
- REFERENCE :
- JPMSAE Journal of Pharmaceutical Sciences. (American Pharmaceutical Assoc., 2215 Constitution Ave., NW, Washington, DC 20037) V.50- 1961- Volume(issue)/page/year: 68,696,1979
Safety Information
| Symbol | GHS02, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H226-H351-H361d |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;Gloves |
| Hazard Codes | Xn:Harmful |
| Risk Phrases | R10;R20/22;R37/38;R40;R41 |
| Safety Phrases | S16-S26-S36/37/39-S45 |
| RIDADR | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | OH2921000 |
| HS Code | 2924299090 |
Customs
| HS Code | 2924299090 |
|---|---|
| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Synonyms
| N-[(Benzyloxy)carbonyl]-L-leucine |
| N-(Benzyloxycarbonyl)-L-leucine (N-(Benzyloxycarbonyl)leucine |
| Z-L-Leucine |
| EINECS 217-960-3 |
| N-Carbobenzyloxy-L-leucine |
| (2S)-4-methyl-2-(phenylmethoxycarbonylamino)pentanoic acid |
| N-Benzyloxycarbonyl-L-leucine |
| Cbz-L-Leu-OH |
| Carbobenzoxyleucine |
| Benzyloxycarbonylleucine |
| dl-Leucine, N-[(phenylmethoxy)carbonyl]- |
| N-(Benzyloxycarbonyl)-L-leucine N-(B |
| (S)-2-(((Benzyloxy)carbonyl)amino)-4-methylpentanoic acid |
| Z-Leu-OH |
| N-Benzyloxycarbonylleucine |
| L-Leucine, N-[(phenylmethoxy)carbonyl]- |
| N-Cbz-L-leucine |
| N-[(Benzyloxy)carbonyl]leucine |
| MFCD00026494 |
| Cbz-L-leucine |
| Leucine, N-[(phenylmethoxy)carbonyl]- |
| Benzyloxycarbonyl-L-leucine |
| N-Carbobenzoxy-L-leucine |
