CAS 76896-80-5|Triacsin C from Streptomyces sp.
| Common Name | Triacsin C from Streptomyces sp. | ||
|---|---|---|---|
| CAS Number | 76896-80-5 | Molecular Weight | 207.272 |
| Density | 0.9±0.1 g/cm3 | Boiling Point | 320.7±45.0 °C at 760 mmHg |
| Molecular Formula | C11H17N3O | Melting Point | 100-102ºC |
| MSDS | USA | Flash Point | 147.7±28.7 °C |
Names
| Name | triacsin c |
|---|---|
| Synonym | More Synonyms |
Triacsin C from Streptomyces sp. BiologicalActivity
| Description | Triacsin C (WS 1228A), a natural intracellular long-chain acyl-CoA synthetases (ACSL) inhibitor, is from Streptomyces aureofaciens. Triacsin C inhibits TAG accumulation into lipid droplets (LD) by suppressing ACSL activity[1]. Triacsin C is found to be highly effective against rotavirus replication[2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| Target | ACSL[1] |
| References | [1]. Dechandt CRP, et al. Triacsin C reduces lipid droplet formation and induces mitochondrial biogenesis in primary rat hepatocytes. J Bioenerg Biomembr. 2017 Oct;49(5):399-411. [2]. Kim Y, et al. Novel triacsin C analogs as potential antivirals against rotavirus infections. Eur J Med Chem. 2012 Apr;50:311-8. |
Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
|---|---|
| Boiling Point | 320.7±45.0 °C at 760 mmHg |
| Melting Point | 100-102ºC |
| Molecular Formula | C11H17N3O |
| Molecular Weight | 207.272 |
| Flash Point | 147.7±28.7 °C |
| Exact Mass | 207.137161 |
| PSA | 53.82000 |
| LogP | 4.02 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.485 |
| InChIKey | NKTGCVUIESDXPU-UHFFFAOYSA-N |
| SMILES | CCCC=CCC=CC=CC=NNN=O |
| Storage condition | -20°C |
Safety Information
| RIDADR | NONH for all modes of transport |
|---|---|
| WGK Germany | 3 |
Articles32
More Articles| Acyl-CoA synthetase as a cancer survival factor: its inhibition enhances the efficacy of etoposide. Cancer Sci. 100(8) , 1556-62, (2009) Lipid metabolism is often elevated in cancer cells and plays an important role in their growth and malignancy. Acyl-CoA synthetase (ACS), which converts long-chain fatty acids to acyl-CoA, is overexpr... | |
| Human intestinal acyl-CoA synthetase 5 is sensitive to the inhibitor triacsin C. World J. Gastroenterol. 17(44) , 4883-9, (2011) To investigate whether human acyl-CoA synthetase 5 (ACSL5) is sensitive to the ACSL inhibitor triacsin C.The ACSL isoforms ACSL1 and ACSL5 from rat as well as human ACSL5 were cloned and recombinantly... | |
| Diacylglycerol enrichment of endoplasmic reticulum or lipid droplets recruits perilipin 3/TIP47 during lipid storage and mobilization. J. Thorac. Cardiovasc. Surg. 284 , 30941-8, (2009) Fatty acid-induced triacylglycerol synthesis produces triacylglycerol droplets with a protein coat that includes perilipin 3/TIP47 and perilipin 4/S3-12. This study addresses the following two questio... |
Synonyms
| (3E)-1-Oxo-3-[(2E,4E,7E)-2,4,7-undecatrien-1-ylidene]triazane |
| 2E,4E,7E-undecatriene-1-triazine |
| Antibiotic WS-1228A |
| WS 1228A |
| Triacsincapprox. |
| triacsin c from streptomyces sp. |
| Triacsin C |
| 2,4,7-Undecatrienal |
| WS1228A |
| Galloflavin |
| 2E,4E,7E-UNDECATRIENE-1-TRIAZENE |
| 2,4,7-Undecatrienal, 2-nitrosohydrazone, (1E,2E,4E,7E)- |
| 1-hydroxy-3-(E,E,E,-2',4',7'-undecatrienylidine)triazene |
