Introduction：Basic information about CAS 81381-50-2|(D-Ala4)-Substance P (4-11), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (D-Ala4)-Substance P (4-11) |
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| CAS Number | 81381-50-2 | Molecular Weight | 940.120 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 1450.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C44H65N11O10S | Melting Point | / |
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| MSDS | / | Flash Point | 831.0±34.3 °C |
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Names
| Name | [D-Ala4]-Substance P (4-11) |
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| Synonym | More Synonyms |
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(D-Ala4)-Substance P (4-11) BiologicalActivity
| Description | [DAla4] Substance P (4-11) is an analog of Substance P (Substance P (HY-P0201)) that inhibits the binding of 125I-Bolton Hunter-conjugated Eledoisin (Eledoisin (HY-P0006)) (IC50 of 0.5 μM) and 125I-Bolton Hunter-conjugated Substance P (IC50 of 0.15 μM) to rat brain cortex membranes[1]. |
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| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Neurokinin ReceptorResearch Areas >>Neurological DiseaseSignaling Pathways >>GPCR/G Protein >>Neurokinin Receptor |
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| In Vitro | Eledoisin 和 Substance P 是速激肽的一类肽成员，它们具有相似的生物活性谱。[DAla4] Substance P (4-11) ([D-Ala0-(5-11)]SP) 抑制 125I-Bolton Hunter-conjugated 偶联的 Eledoisin 和 125I-Bolton Hunter 偶联的 Substance P 与大鼠大脑皮层膜的结合[1]。 |
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| References | [1]. M A Cascieri, et al. Demonstration of two distinct tachykinin receptors in rat brain cortex. J Biol Chem. 1985 Feb 10;260(3):1501-7. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 1450.5±65.0 °C at 760 mmHg |
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| Molecular Formula | C44H65N11O10S |
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| Molecular Weight | 940.120 |
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| Flash Point | 831.0±34.3 °C |
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| Exact Mass | 939.463684 |
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| PSA | 384.29000 |
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| LogP | 0.37 |
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| Vapour Pressure | 0.0±0.3 mmHg at 25°C |
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| Index of Refraction | 1.578 |
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| InChIKey | UBTXIXKYOWTVEU-UHFFFAOYSA-N |
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| SMILES | CSCCC(NC(=O)C(CC(C)C)NC(=O)CNC(=O)C(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)C(CCC(N)=O)NC(=O)C(CCC(N)=O)NC(=O)C(C)N)C(N)=O |
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Synonyms
| D-Alanyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl-L-methioninamide |
| Substance P,fragment 4-11,(D-Ala4) |
| D-ALA-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 |
| H-D-ALA-GLN-GLN-PHE-PHE-GLY-LEU-MET-NH2 |
| L-Methioninamide, D-alanyl-L-glutaminyl-L-glutaminyl-L-phenylalanyl-L-phenylalanylglycyl-L-leucyl- |
| SUBSTANCE P OCTAPEPTIDE D-ALA-4-FRAGMENT 4-11) |
| (D-ALA4)-SUBSTANCE P (4-11) |
