CAS 113274-57-0|Acetyl-Hirudin (55-65) (desulfated)

Introduction:Basic information about CAS 113274-57-0|Acetyl-Hirudin (55-65) (desulfated), including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameAcetyl-Hirudin (55-65) (desulfated)
CAS Number113274-57-0Molecular Weight1453.50000
Density/Boiling Point/
Molecular FormulaC66H92N12O25Melting Point/
MSDSChineseUSAFlash Point/

Names

NameAc-Hirudin (55-65) (desulfated)
SynonymMore Synonyms

Chemical & Physical Properties

Molecular FormulaC66H92N12O25
Molecular Weight1453.50000
Exact Mass1452.63000
PSA598.43000
LogP1.95970
InChIKeyIEAUQSWIFZNYCL-UHFFFAOYSA-N
SMILESCCC(C)C(NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)O)NC(=O)C(Cc1ccccc1)NC(=O)C(CC(=O)O)NC(C)=O)C(=O)N1CCCC1C(=O)NC(CCC(=O)O)C(=O)NC(CCC(=O)O)C(=O)NC(Cc1ccc(O)cc1)C(=O)NC(CC(C)C)C(=O)NC(CCC(N)=O)C(=O)O

Safety Information

Personal Protective EquipmentEyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
RIDADRNONH for all modes of transport
WGK Germany3

Articles4

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Lepirudin blunts endotoxin-induced coagulation activation.

Blood 95 , 1729-1734, (2000)

During sepsis, lipopolysaccharide (LPS) triggers the development of disseminated intravascular coagulation (DIC) via the tissue factor-dependent pathway of coagulation resulting in massive thrombin ge...

Thrombin-dependent MMP-2 activity is regulated by heparan sulfate.

J. Biol. Chem. 285 , 41270-41279, (2010)

Like most metalloproteases, matrix metalloprotease 2 (MMP-2) is synthesized as a zymogen. MMP-2 propeptide plays a role in inhibition of catalytic activity through a cysteine-zinc ion pairing, disrupt...

Chemical compensation in macromolecular bridge-binding to thrombin.

Biochemistry 32 , 2947-2953, (1993)

The binding energetics of eight synthetic peptides capable of interfering with thrombin function have been studied by steady-state measurements and clotting assays. The synthetic peptides are bifuncti...

Synonyms

ACETYL-HIRUDIN (55-65) (DESULFATED)
N-acetyl-hirudin fragment 55-65
ACETYL-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN
AC-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN-OH
ac-hirudin fragment 55-65 non-sulfated
N-ACETYL-HIRUDIN AC-FRAGMENT 55-65 NON-SULFATED
AC-ASP-PHE-GLU-GLU-ILE-PRO-GLU-GLU-TYR-LEU-GLN
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