CAS 4330-99-8|Alimemazine hemitartrate
Introduction：Basic information about CAS 4330-99-8|Alimemazine hemitartrate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Alimemazine hemitartrate | ||
|---|---|---|---|
| CAS Number | 4330-99-8 | Molecular Weight | 373.49 |
| Density | / | Boiling Point | / |
| Molecular Formula | C18H22N2S.1/2C4H6O6 | Melting Point | >300 °C(lit.) |
| MSDS | / | Flash Point | / |
| Symbol | GHS06 | Signal Word | Danger |
Names
| Name | Alimemazine hemitartrate |
|---|---|
| Synonym | More Synonyms |
Alimemazine hemitartrate BiologicalActivity
| Description | Alimemazine hemitartrate is a phenothiazine derivative that is generally used as an antipruritic agent and also a hemagglutinin (HA)-receptor antagonist. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Neurological DiseaseResearch Areas >>Inflammation/Immunology |
| Target | HA receptor[1] |
| References | [1]. Singh B, et al. Bioanalytical method development and validation of alimemazine in human plasma by LC-MS/MS and its application in bioequivalence studies. J Pharm Bioallied Sci. 2013 Oct;5(4):257-64. |
Chemical & Physical Properties
| Melting Point | >300 °C(lit.) |
|---|---|
| Molecular Formula | C18H22N2S.1/2C4H6O6 |
| Molecular Weight | 373.49 |
| PSA | 178.62000 |
| LogP | 6.98140 |
| InChIKey | AJZJIYUOOJLBAU-RNKHSWPKSA-N |
| SMILES | CC(CN(C)C)CN1c2ccccc2Sc2ccccc21.CC(CN(C)C)CN1c2ccccc2Sc2ccccc21.O=C(O)C(O)C(O)C(=O)O |
| Storage condition | Refrigerator |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 210 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 110 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,41,1982
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 140 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 33 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- 27ZQAG "Psychotropic Drugs and Related Compounds," 2nd ed., Usdin, E., and D.H. Efron, Washington, DC, 1972 Volume(issue)/page/year: -,57,1972 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X5558 No. of Facilities: 137 (estimated) No. of Industries: 1 No. of Occupations: 3 No. of Employees: 1472 (estimated) No. of Female Employees: 835 (estimated)
Safety Information
| Symbol | GHS06 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 |
| Precautionary Statements | Missing Phrase - N15.00950417 |
| Hazard Codes | Xn |
| Risk Phrases | 20/21/22 |
| Safety Phrases | S36 |
| RIDADR | 3249 |
| RTECS | SO6475000 |
| Packaging Group | III |
| Hazard Class | 6.1(b) |
| HS Code | 2934300000 |
Customs
| HS Code | 2934300000 |
|---|---|
| Summary | 2934300000. other compounds containing in the structure a phenothiazine ring-system (whether or not hydrogenated), not further fused. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Trimeprazine Tartrate |
| 10-[3-(Dimethylamino)-2-methylpropyl]phenothiazine Tartrate |
| 10H-Phenothiazine-10-propanamine, N,N,β-trimethyl-, 2,3-dihydroxybutanedioate (1:1) (salt) |
| Alimemazine |
| EINECS 224-368-9 |
| N,N,2-trimethyl-3-(10H-phenothiazin-10-yl)propan-1-amine 2,3-dihydroxybutanedioate (1:1) |
| N,N,2-Trimethyl-3-(10H-phenothiazin-10-yl)-1-propanamine 2,3-dihydroxysuccinate (1:1) |
| MFCD00242594 |
