Introduction：Basic information about CAS 1043-21-6|Pirenoxine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Pirenoxine |
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| CAS Number | 1043-21-6 | Molecular Weight | 308.25 |
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| Density | 1.7g/cm3 | Boiling Point | 515.8ºC at 760mmHg |
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| Molecular Formula | C16H8N2O5 | Melting Point | 247-248ºC |
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| MSDS | / | Flash Point | 265.7ºC |
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Names
| Name | 1,5-dioxo-4H-pyrido[3,2-a]phenoxazine-3-carboxylic acid |
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| Synonym | More Synonyms |
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Pirenoxine BiologicalActivity
| Description | Pirenoxine (Catalin K) is a potent antioxidant. Pirenoxine shows anti-presbyopic activity. Pirenoxine has the potential for the research of cataracts[1][2]. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Metabolic Disease |
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| In Vivo | Pirenoxine (0.005% pirenoxine；滴眼液) 抑制晶状体硬化并防止老花眼的发展[2]。 Animal Model: Six-week-old male Sprague-Dawley rats[2] Dosage: 0.005% pirenoxine Administration: Eye drop Result: Significantly suppressed lens hardening. |
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| References | [1]. Upaphong P, et al. The Possible Positive Mechanisms of Pirenoxine in Cataract Formation. Int J Mol Sci. 2022 Aug 21;23(16):9431. [2]. Tsuneyoshi Y, et al. Suppression of presbyopia progression with pirenoxine eye drops: experiments on rats and non-blinded, randomized clinical trial of efficacy. Sci Rep. 2017 Jul 28;7(1):6819. |
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Chemical & Physical Properties
| Density | 1.7g/cm3 |
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| Boiling Point | 515.8ºC at 760mmHg |
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| Melting Point | 247-248ºC |
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| Molecular Formula | C16H8N2O5 |
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| Molecular Weight | 308.25 |
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| Flash Point | 265.7ºC |
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| Exact Mass | 308.04300 |
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| PSA | 113.52000 |
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| LogP | 2.24480 |
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| Vapour Pressure | 1.83E-11mmHg at 25°C |
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| Index of Refraction | 1.793 |
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| InChIKey | OKPNYGAWTYOBFZ-UHFFFAOYSA-N |
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| SMILES | O=C(O)c1cc(=O)c2c3nc4ccccc4oc-3cc(=O)c2[nH]1 |
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Synonyms
| 1-hydroxy-5-oxo-5H-pyrido[3,2-a]-phenoxazine-3-carboxylic acid |
| Pirenoxina [Spanish] |
| 1,5-dioxo-1,5-dihydro-4H-pyrido[3,2-a]phenoxazine-3-carboxylic acid |
| pirenoxine |
| Pirenoxinum |
| EINECS 213-872-4 |
| 1-Hydroxy-pyrido-5-phenoxazon-3-carbonsaeure |
| Pirenoxinum [Latin] |
| Catalin |
| Catalin-K (TN) |
| MFCD00867148 |
| Pirenoxina |
| pirfenoxone |
