CAS 485-72-3|Formononetin
| Common Name | Formononetin | ||
|---|---|---|---|
| CAS Number | 485-72-3 | Molecular Weight | 268.264 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 479.4±45.0 °C at 760 mmHg |
| Molecular Formula | C16H12O4 | Melting Point | 256-260 °C |
| MSDS | ChineseUSA | Flash Point | 183.4±22.2 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | formononetin |
|---|---|
| Synonym | More Synonyms |
Formononetin BiologicalActivity
| Description | Formononetin (Formononetol; Flavosil) is a bioactive component extracted from the red clover; inhibits the proliferation of DU-145/PC-3 cells in a dose-dependent manner.IC50 value:Target: anti-cancer in vitro: formononetin inhibited the proliferation of DU-145 cells in a dose-dependent manner. DU-145 cells treated with different concentrations of formononetin displayed obvious morphological changes of apoptosis under fluorescence microscopy. In addition, formononetin increased the proportion of early apoptotic DU-145 cells, down-regulated the protein levels of Bcl-2 and up-regulated those of RASD1 and Bax [1]. Formononetin significantly inhibited the cell growth of PC-3 in a dose-dependent manner, but no such effect was observed in RWPE1 cells. Formononetin treatment contributed to the reduced Bcl-2 protein level and the elevated Bax expression in PC-3 cells, thereby resulting in the increasing Bax/Bcl-2 ratios. Furthermore, the phosphorylated level of p38 in PC-3 cells was activated through the FN treatment, whereas the endogenous Akt phosphorylation was blocked [2]. Compared with the control, formononetin inhibited the proliferation of MCF-7 cells and effectively induced cell cycle arrest. The levels of p-IGF-1?R, p-Akt, cyclin D1 protein expression, and cyclin D1 mRNA expression were also downregulated [3].in vivo: formononetin also prevented the tumor growth of human breast cancer cells in nude mouse xenografts [3]. |
|---|---|
| Related Catalog | Natural Products >>FlavonoidsResearch Areas >>Cancer |
| References | [1]. Liu XJ, et al. Up-regulating of RASD1 and apoptosis of DU-145 human prostate cancer cells induced by formononetin in vitro. Asian Pac J Cancer Prev. 2014;15(6):2835-9. [2]. Zhang X, et al. Formononetin induces apoptosis in PC-3 prostate cancer cells through enhancing the Bax/Bcl-2 ratios and regulating the p38/Akt pathway. Nutr Cancer. 2014;66(4):656-61. [3]. Chen J, et al. Formononetin induces cell cycle arrest of human breast cancer cells via IGF1/PI3K/Akt pathways in vitro and in vivo. Horm Metab Res. 2011 Sep;43(10):681-6. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 479.4±45.0 °C at 760 mmHg |
| Melting Point | 256-260 °C |
| Molecular Formula | C16H12O4 |
| Molecular Weight | 268.264 |
| Flash Point | 183.4±22.2 °C |
| Exact Mass | 268.073547 |
| PSA | 59.67000 |
| LogP | 2.96 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.641 |
| InChIKey | HKQYGTCOTHHOMP-UHFFFAOYSA-N |
| SMILES | COc1ccc(-c2coc3cc(O)ccc3c2=O)cc1 |
| Storage condition | Refrigerator |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319-H335 |
| Precautionary Statements | P280-P305 + P351 + P338-P337 + P313 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S37/39-S26-S36 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2932999099 |
Customs
| HS Code | 2932999099 |
|---|---|
| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles56
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Synonyms
| 4H-1-Benzopyran-4-one, 7-hydroxy-3-(4-methoxyphenyl)- |
| 7-hydroxy-4'-methoxy-Isoflavone (8CI) |
| 7-Hydroxy-3-(4-methoxyphenyl)-4H-chromen-4-one |
| Formononetol |
| 4'-O-methyl-daidzein |
| 4H-1-Benzopyran-4-one, 7-hydroxy-3- (4-methoxyphenyl)- |
| BIOCHANIN B |
| ForMonentin |
| BIOCHANIN A |
| Flavosil |
| 7-Hydroxy-4'-methoxyisoflavone |
| Neochanin |
| Myconate |
| MFCD00016948 |
| BiocaninB |
| FORMONETIN |
| 7-Hydroxy-3-(4-methoxyphenyl)-4H-1-benzopyran-4-one |
| EINECS 207-623-9 |
| Formononetin |
| 7-Hydroxy-3-(4-methoxyphenyl)chromone |
| forMonoetin |
