CAS 3736-81-0|Diloxanide furoate
| Common Name | Diloxanide furoate | ||
|---|---|---|---|
| CAS Number | 3736-81-0 | Molecular Weight | 328.14700 |
| Density | / | Boiling Point | / |
| Molecular Formula | C14H11Cl2NO4 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | [4-[(2,2-dichloroacetyl)-methylamino]phenyl] furan-2-carboxylate |
|---|---|
| Synonym | More Synonyms |
Diloxanide furoate BiologicalActivity
| Description | Diloxanide furoate is a luminal amebicide used in the treatment of Amebiasis, is considered the luminal agent of choice for mild intestinal amebiasis or asymptomatic cyst carriers. |
|---|---|
| Related Catalog | Signaling Pathways >>Anti-infection >>ParasiteResearch Areas >>Infection |
| References | [1]. Castro Hermida JA, et al. Inhibition of Cryptosporidium infection in mice treated with a cyclodextrin inclusion complex with diloxanide furoate. Parasitol Res. 2001 Jun;87(6):449-52. [2]. Martínez-Castillo M, et al. Flavonoids as a Natural Treatment Against Entamoeba histolytica. Front Cell Infect Microbiol. 2018 Jun 22;8:209. |
Chemical & Physical Properties
| Molecular Formula | C14H11Cl2NO4 |
|---|---|
| Molecular Weight | 328.14700 |
| Exact Mass | 327.00700 |
| PSA | 59.75000 |
| LogP | 3.26530 |
| InChIKey | BDYYDXJSHYEDGB-UHFFFAOYSA-N |
| SMILES | CN(C(=O)C(Cl)Cl)c1ccc(OC(=O)c2ccco2)cc1 |
| Storage condition | 2-8℃ |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 710 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- AECTCV Archives of Environmental Contamination and Toxicology. (Springer-Verlag New York, Inc., Service Center, 44 Hartz Way, Secaucus, NJ 070944) V.1- 1973- Volume(issue)/page/year: 14,111,1985
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| Safety Phrases | 36 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| RTECS | LV1821800 |
Articles26
More Articles| Kinetic spectrophotometric H-point standard addition method for the simultaneous determination of diloxanide furoate and metronidazole in binary mixtures and biological fluids. Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 114 , 592-8, (2013) Simple, reliable, and sensitive kinetic spectrophotometric method has been developed for the simultaneous determination of diloxanide furoate and metronidazole using H-point standard addition method (... | |
| Validated chromatographic and spectrophotometric methods for analysis of some amoebicide drugs in their combined pharmaceutical preparation. Pak. J. Pharm. Sci. 26(1) , 175-83, (2013) This work is concerned with development and validation of chromatographic and spectrophotometric methods for analysis of mebeverine HCl (MEH), diloxanide furoate (DF) and metronidazole (MET) in Dimetr... | |
| A misguided 'pill in the pocket' approach with flecainide leading to cardiac arrest. BMJ Case Rep. 2012 , doi:10.1136/bcr-2012-006868, (2012) |
Synonyms
| Amebiazol |
| Miforon |
| MFCD00083302 |
| Diclofurazol |
| Diloxanid furoate |
| Furamide (amebicide) |
| Entamide furoate |
| Furentomin |
| Entamide 2-furoate |
| Histomibal |
| DILOXANIDE FUROATE |
| EINECS 223-108-1 |
