Introduction：Basic information about CAS 80225-53-2|Rosmanol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Rosmanol |
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| CAS Number | 80225-53-2 | Molecular Weight | 346.41700 |
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| Density | 1.33 | Boiling Point | 574.186ºC at 760 mmHg |
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| Molecular Formula | C20H26O5 | Melting Point | / |
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| MSDS | / | Flash Point | 205.663ºC |
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Names
| Name | Rosmanol |
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| Synonym | More Synonyms |
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Rosmanol BiologicalActivity
| Description | Rosmanol could inhibit the oxidation of low density lipoprotein (LPL) and significantly inhibit lipopolysaccharide induced iNOS and COX-2 expression, with anti-inflammatory effect. |
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| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/ImmunologyNatural Products >>Phenols |
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| In Vitro | Rosmanol exhibits the strongest inhibition on cell viability with IC50 approximately 42 μM. Rosmanol might suppress cancer cell proliferation or induce cancer cell undergoing apoptosis that lead to cell growth-inhibition. With 50 μM of Rosmanol treatment, the percentage of COLO 205 cells undergoing apoptosis increase dramatically from 9 h (29%) to 24 h (51%). Within 24 h of treatment with 50 μM Rosmanol, COLO 205 cells exhibit significant morphological changes and chromosomal condensation, which is indicative of apoptotic cell death[1]. Carnosol is a lipid protector against attack by O2[2]. |
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| References | [1]. Cheng AC, et al. Rosmanol potently induces apoptosis through both the mitochondrial apoptotic pathway and death receptor pathway in human colon adenocarcinoma COLO 205 cells. Food Chem Toxicol. 2011 Feb;49(2):485-93. [2]. Loussouarn M, et al. Carnosic Acid and Carnosol, Two Major Antioxidants of Rosemary, Act through Different Mechanisms. Plant Physiol. 2017 Nov;175(3):1381-1394. |
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Chemical & Physical Properties
| Density | 1.33 |
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| Boiling Point | 574.186ºC at 760 mmHg |
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| Molecular Formula | C20H26O5 |
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| Molecular Weight | 346.41700 |
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| Flash Point | 205.663ºC |
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| Exact Mass | 346.17800 |
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| PSA | 86.99000 |
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| LogP | 3.25770 |
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| Index of Refraction | 1.625 |
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| InChIKey | LCAZOMIGFDQMNC-FORWCCJISA-N |
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| SMILES | CC(C)c1cc2c(c(O)c1O)C13CCCC(C)(C)C1C(OC3=O)C2O |
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| Storage condition | 2-8℃ |
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Safety Information
Customs
| HS Code | 2932999099 |
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| Summary | 2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| Oxydesaminoisorosmaricin |
| (4bR,8aS,9S,10S)-3,4,10-Trihydroxy-2-isopropyl-8,8-dimethyl-6,7,8,8a,9,10-hexahydro-5H-9,4b-(epoxymethano)phenanthren-12-one |
