Introduction：Basic information about CAS 43043-74-9|Deoxyshikonin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Deoxyshikonin |
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| CAS Number | 43043-74-9 | Molecular Weight | 272.296 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 503.7±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H16O4 | Melting Point | 91ºC |
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| MSDS | / | Flash Point | 272.5±26.6 °C |
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Names
| Name | 5,8-dihydroxy-2-(4-methylpent-3-enyl)naphthalene-1,4-dione |
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| Synonym | More Synonyms |
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Deoxyshikonin BiologicalActivity
| Description | Deoxyshikonin is isolated from Lithospermum erythrorhizon Sieb with antitumor activity. Deoxyshikonin increases the expression of VEGF-C and VEGF-A mRNA in HMVEC-dLy, promotes HIF-1α and HIF-1β subunit interaction and binds to specific DNA sequences targeted by HIF, indicates a prolymphangiogenesis as well as a proangiogenesis effect in vitro[1]. Deoxyshikonin shows significant synergic antimicrobial activity with tetracycline against S. pneumonia (MIC=17 μg/mL), also shows significantly inhibitory activities against MRSA[2]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>Cardiovascular DiseaseResearch Areas >>InfectionSignaling Pathways >>Metabolic Enzyme/Protease >>HIF/HIF Prolyl-HydroxylaseSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. Prangsaengtong O, et al. Enhancement of Lymphangiogenesis In Vitro via the Regulations of HIF-1α Expression and Nuclear Translocation by Deoxyshikonin. Evid Based Complement Alternat Med. 2013;2013:148297. [2]. Zhang S, et al. Antibacterial effects of Traditional Chinese Medicine monomers against Streptococcus pneumoniae via inhibiting pneumococcal histidine kinase (VicK). Front Microbiol. 2015 May 20;6:479. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 503.7±50.0 °C at 760 mmHg |
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| Melting Point | 91ºC |
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| Molecular Formula | C16H16O4 |
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| Molecular Weight | 272.296 |
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| Flash Point | 272.5±26.6 °C |
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| Exact Mass | 272.104858 |
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| PSA | 74.60000 |
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| LogP | 4.72 |
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| Vapour Pressure | 0.0±1.3 mmHg at 25°C |
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| Index of Refraction | 1.611 |
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| InChIKey | VOMDIEGPEURZJO-UHFFFAOYSA-N |
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| SMILES | CC(C)=CCCC1=CC(=O)c2c(O)ccc(O)c2C1=O |
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| Storage condition | 2-8C |
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Safety Information
| Safety Phrases | 22-24/25 |
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| HS Code | 2914690090 |
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Customs
| HS Code | 2914690090 |
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| Summary | 2914690090 other quinones。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:5.5%。General tariff:30.0% |
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Synonyms
| 1'O-deoxyshikonin |
| ARNEBIN-7 |
| 5,8-Dihydroxy-2-(4-methyl-3-penten-1-yl)-1,4-naphthoquinone |
| deoxyalkannin |
| 5,8-Dihydroxy-2-(4-methyl-3-pentenyl)-1,4-naphthalenedione |
| 11-Deoxyalkannin |
| 1,4-Naphthalenedione, 5,8-dihydroxy-2-(4-methyl-3-pentenyl)- |
| 5,8-Dihydroxy-2-(4-methyl-pent-3-enyl)-1,4-naphthoquinone |
| 1,4-Naphthalenedione, 5,8-dihydroxy-2-(4-methyl-3-penten-1-yl)- |
| 5,8-Dihydroxy-2-(4-methyl-3-pentenyl)naphthoquinone |
| deoxyshikonin |
| 5,8-Dihydroxy-2-(4-methylpent-3-en-1-yl)-1,4-naphthoquinone |
