CAS 6042-32-6|TAUROLITHOCHOLIC ACID SODIUM SALT
| Common Name | TAUROLITHOCHOLIC ACID SODIUM SALT | ||
|---|---|---|---|
| CAS Number | 6042-32-6 | Molecular Weight | 505.68600 |
| Density | / | Boiling Point | / |
| Molecular Formula | C26H44NNaO5S | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
Names
| Name | taurolithocholic acid sodium salt |
|---|---|
| Synonym | More Synonyms |
TAUROLITHOCHOLIC ACID SODIUM SALT BiologicalActivity
| Description | Taurolithocholic acid sodium salt, a potent cholestatic agent, is a potent Ca2+ agonist[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Calcium ChannelResearch Areas >>Metabolic Disease |
| In Vitro | Taurolithocholic acid (TLCA) at low concentrations (5 µM) tends to selectively increase the membrane-associated fraction of the e-isoform of PKC by 44.1% ± 40.2%[1]. TLCA (10 µM) selectively induces translocation of theε-isoform of PKC to the hepatocellular membranes, a key step for activation of mobile PKC isoforms[1]. |
| In Vivo | Taurolithocholic acid (TLCA) exerts cholestatic effects via PI3K-dependent mechanisms in perfused rat Livers and rat hepatocyte couplets[2]. |
| References | [1]. U Beuers, et al. Modulation of protein kinase C by taurolithocholic acid in isolated rat hepatocytes. Hepatology. 1999 Feb;29(2):477-82. [2]. Ulrich Beuers, et al. Taurolithocholic acid exerts cholestatic effects via phosphatidylinositol 3-kinase-dependent mechanisms in perfused rat livers and rat hepatocyte couplets. J Biol Chem. 2003 May 16;278(20):17810-8. |
Chemical & Physical Properties
| Molecular Formula | C26H44NNaO5S |
|---|---|
| Molecular Weight | 505.68600 |
| Exact Mass | 505.28400 |
| PSA | 114.91000 |
| LogP | 5.55560 |
| InChIKey | YWXCPBUMOMIAJB-HRHHVWJRSA-N |
| SMILES | CC(CCC(=O)NCCS(=O)(=O)O)C1CCC2C3CCC4CC(O)CCC4(C)C3CCC12C.[Na] |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| RIDADR | NONH for all modes of transport |
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Synonyms
| sodium taurolithocholic acid |
| N-(3a-Hydroxy-5-cholan-24-oyl)taurine Monosodium Salt |
| sodium taurolithocholate |
| SODIUM TAUROLITHOCHOLATE SODIUM SALT |
| 5BETA-CHOLANIC ACID-3ALPHA-OL 24-N-(2-SULFOETHYL)AMIDE SODIUM |
| taurolithocholic acid sodium |
| TAUROLITHIOCHOLIC ACID SODIUM |
